Posted 6/30/2015 4:34 PM (GMT -6)
Hi and welcome to Healingwell,
I don't know anything about these 2 specific mutations I'm thinking they're probably rarer ones.
Different mutations cause the CF gene to be faulty in different ways. So, some mutations can effect the lungs more and some can effect the guts more. However the CF gene also interects with other genes in the body so 2 people with the same CF genetic mutation can be completely different in how the gene effects them.
For example both my brother and I have DF508 as our CF genes, he can work full time, hardly picks up any infections and hasn't needed any antibiotics for over 3 years, however he has always suffered massively with his bowels and gets a lot of bowel obstructions. On the other hand, I have infection after infection, get 2-6 months between IV antibiotics and don't get too many bowel issues.
Environmental issues such as pollution, exposure to bacteria, such as early school age where people build up most of their resistances to viruses which can help them later on in life to be better at fighting off bugs. Or where there is too much exposure to funguses, pseudomonas and other bacteria which can have long term negative effects.
These things can all effect the impact on our lungs and how the cf gene might operate.