Anti-depressants 4 ppl genetically prone 2 depression

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New Member

Date Joined Feb 2008
Total Posts : 2
   Posted 2/29/2008 4:38 PM (GMT -6)   

I've been on Effexor for 4 years. I've just been told I probably have a genetic predisposition to depression because both my parents have/had depression (my Dad comitted suicide).

What I'm wondering is...... what is the best anti-depressant for people who are genetically prone to depression?

Is anyone else out there in my position?? What anti-depressants are you on?

Some forms of depression are caused by stressful life events however for people like me who have depression because they have sadly inherited it from their parents, I'm wondering what is the best anti-depressant in this situation?

I realise the best person to talk to about this is my Doctor and I will visit my local dr soon. It's just nice chatting with people who have experience being on anti-depressants.

Thanks very much.

getting by
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Date Joined Sep 2007
Total Posts : 42612
   Posted 2/29/2008 5:03 PM (GMT -6)   
I inherited depression from my parents too. They were both alcoholics also. So I don't know if that caused the depression or not. I am taking effexor (375mg) daily. And I was told that I would be on it for the rest of my life. I don't know if that helps you any. I do believe the medications work with our brain chemicals. I don't know if that is genetic or not, but I would imagine. Hopefully you will get some better responses.

fibromyalgia, Chronic fatigue, depression,allergies

New Member

Date Joined Feb 2008
Total Posts : 2
   Posted 2/29/2008 6:04 PM (GMT -6)   

Hello Karen,

Thanks for your reply :)

Sorry to hear that you inherited depression from your parents also. It's encouraging feeling like yr not the only one.

We are taking the same medication - Efexor. For the past few years, I've been on 75mg/day of Efexor. Then I moved house to the other side of town so I changed doctors. My new doctor saw the dosage I was on and said to me that 75mg of Efexor is quite a low dosage so she doubled it to 150mg/day.

I've been on 150mg now for the last roughly 6-12mths (can't quite remember). My new doctor and my psychologist both asked me recently do I feel that Efexor is working for me? And I really didn't know how to answer. I can only assume its working but I wish it worked better.

I know antidepressants aren't bandaids that will make me numb and unable to ever feel sad again... BUT I've been on Efexor for 4 years now and I still have suicidal thoughts!!! This is what is making me reasearch anti-depressants because I'm wondering is there possibly another drug out there that could be better suited for me than Efexor?? Or maybe Efexor is great for me but I just need to be on a higher dosage?? I don't know.

Karen, were you ever on a lower dosage of Efexor? How long have you been on Efexor? In what specific ways can you see that Efexor helps you/works for you? thanks heaps :)

New Member

Date Joined Feb 2008
Total Posts : 1
   Posted 2/29/2008 6:12 PM (GMT -6)   

I just starting doing research, again, to see what antidepressants I could discuss w/ my dr. and found this site. My heart goes out to those who have chronic or lifetime depression b/c I am one of them. I have been depressed for a long as I can remember. I go to therapy, I've been on antidepressants but my brother passed away a year ago and my depression is almost at it's worst. Before I never could cry and now I do all the time.

Before he passed I got on Cymbalta which replaced my Paxil (side affects affecting my sexual relationship w/ my boyfriend) and  was added to my Welbutrin. Things seemed to have improved. I felt more alive - less of that hazzy existence. And then the bad news. I don't know what to do. Will I add a third medication? - My mg.s are maxed out on these two. I don't know if this is situational or am I becoming more tollarant?

I accept these medications will be in my life forever mostlikely, and that is o.k. I mean I was an active alcoholic and that had to have done much more damage phsyologically and psycologically plus I've just had enough of the depression. "That which does not kill you..." Well I'm not getting any stronger, I'm getting weaker.

It's about the quality of life. The side effects for me are worth it. The stress probably shaves more off my life than the medication ever could. You owe it to yourself to take care of yourself and medication just might be the way. It's not like you can't stop if you want to. Your free to decide obviously.

Before I went to my doctor I did some reading online. I saw that Wellbutrin is also used for ADD which I have never been diagnosed w/ but most likely have and the Paxil could help OCD which I experience from time to time. There might be meds that can kill two birds w/ one stone and like everyone says, you really can't know the side affects til you take it yourself. I know, I am frustrated too. Another possible med change, but this is the rest of my life so I have time but might as well figure it out now.

Good luck to you. I wish you the happiness you probably deserve.



getting by
Forum Moderator

Date Joined Sep 2007
Total Posts : 42612
   Posted 2/29/2008 7:28 PM (GMT -6)   

Hi Leith,

I have been of effexor for about 14 years as far as I can remember.  I did try to stop it thinking I was better, then realized I was feeling better because of it.  And I didn't taper off right and the withdrawal symptoms were awful.  I took serzone for a while and went back on effexor.  I use to take 150mg a day but have been taking the max (375) for about five years.  I also take abilify for mood stablization and it helps with obsessive thinking.  I have been doing a lot better with the two together.  Also take xanax for anxiety.  But have cut down on that since I have cut back on caffiene.

Good luck on your meds

Hugs, Karen

fibromyalgia, Chronic fatigue, depression,allergies

Veteran Member

Date Joined Dec 2005
Total Posts : 3036
   Posted 3/1/2008 7:44 AM (GMT -6)   
My mom just started taking anti depressants,something she should have done moons ago.

My brother has bad anxiety and takes son is bipolar

So ohh yeah it comes down the line!

Mod- Depression

Chronic Depression, Panic Attacks,Anxiety Attacks,Anorexia

Regular Member

Date Joined Nov 2007
Total Posts : 146
   Posted 3/1/2008 8:53 AM (GMT -6)   
HI ,

Just wanted to add my opinion, my name (badgenetics) comes from just that. My mother is agoraphobic with bouts of depression. She has been on Zoloft and was actually able to get a job, in her 50's! She and my father are both alcholics and my brother has major depression. In my mind, there is a very strong genetic link, I truly beleive my issues stem about 75% from brain chemistry and perhaps 25% from life experience/trauma.

I suppose if we did not have a chemical imbalance, meds could not help us. I have been on Lexapro and Klonopin, Klonopin for 2 years and Lex just for about a month.

I won't ever go back to how I was. However I do believe, dispite our afflictions, we and our offspring can have a lot to contribute to the world. I suppose everyone has their cross to bear.
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