Dopamine and SSRIS

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Regular Member

Date Joined Jul 2008
Total Posts : 28
   Posted 7/27/2008 6:53 AM (GMT -6)   
I just learned something interesting about SSRIS and dopamine. SSRIS not only inhibit the uptake of seritonin in the brain, they also "hijack" the uptake of dopamine and cause it to transfer to the seritonin receptors instead. So those using SSRIS have less dopamine available in their brains, which may explain the apathy and "whatever" feeling of not caring about much that many users of SSRIS report. Now since Parkinson's Disease is "caused "primarily by the brain no longer producing sufficent amounts of dopamine, the pleasure endorphin, and since up to 50% of Parkinson's patients suffer from depression, this would seem to indicate that SSRIS are a rather poor choice for treatment of depression in Parkinson's patients, and that other meds and treatments need to be more aggresively explored.
Parkinson's disease, depression, anxiety disorder

"If you pursue evil with pleasure the pleasure passes away but the evil remains, if you pursue good with labor the good remains and the labor is not wasted."

getting by
Forum Moderator

Date Joined Sep 2007
Total Posts : 42499
   Posted 7/27/2008 11:46 AM (GMT -6)   
This is truly interesting, I don't understand a lot about the dopamine and the seratonin. But trying to learn. Half the time I don't even know how my anti d's work. But they do.

I am sorry that you suffer with parkinsons. How are you doing with that? It sounds like you have some good information. Are you going to talk to the doctor about that? Maybe there are some medications that can treat both. I wish you luck with this.

Keep posting, we love to hear from you. You are a wonderful addition to the forum and Lunardance, we care about you here.

I hope that you are having a wonderful day
hugs, Karen...
  Moderator-Depression and fibromyalgia
fibromyalgia, Chronic fatigue, depression,allergies

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 7/27/2008 9:41 PM (GMT -6)   

Hi lunar,

The mechinisms of how the chemicals of these drugs work on the brain is very complicated.  Here is a link you may find interesting.

Take care and please remember I am not a professional so it is confusing for me too. :-)



Kitt, Moderator: Anxiety, Panic & Depression 
*~* *~*
Not a mental health professional of any kind
It is health that is real wealth and not pieces of gold and silver.~Mahatma Gandhi~
Clickable Link: Anxiety-Panic Resources

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