I was on Cymbalta awhile. It helped a little. The problem was the side effect of sweating. Major, bizarre amounts of sweat. One evening, it was in the 70's. We went to an outside event and my son's boss was going to be there. Just normal walking around caused so much sweat my son said I looked like I had run a marathon. I think he was embarrassed. Sweat was dripping off my hair,(I am female). I was wiping my face with tissue because drops were running down constantly. I did not know it but the tissue had begun to shred and I had bits of tissue all over my face and chest. No one else was sweating. My doctor said "your body will boil if you don't sweat." I told him I did not have to worry about
that. He gave me some pill for Parkinson's which I don't have. He gave it to me because it had the side effect of depressing sweating. The side effects were supposed to fight it out. It did not work. I still sweated uncontrollably. Finally, I found meaningful work and felt so much better I did not need an anti-depressant. I stopped taking it 18 months ago.
Ulcerative Colitis since about 1976
Pan colitis since at least 1994
30 years with UC and never had a flare until MD gave massive dose of Magnesiun while hospitalized for bronchitis. I had no family doctor so they had just assigned me to the house doctor. Then was hospitalized a few days for moderate flare. No flares since. But now I have a family doctor.