I also have problems taking some meds. I never know what my reaction will be when I swallow a new pill. I even react to Vit. B12 and a B12 shot once threw me into a 10 month deep, deep depression. I take Prozac (I'm now down to the minimum per day). I can't take the generic form, fluoxitine. The Pharmacists shake their heads at me. Some have even said there isn't any difference, but body says there is.
Recently, my doctor sent me to the lab for extensive blood work. It showed that I have one copy of a mutated gene, the MTHFR Mutation, copy C677T. I'm mildly depressed, extremely tired most of the time, have arthritis and muscle soreness, and I tested highly allergic to 70 items with scratch tests last month. The doctor associated the MTHFR Mutation to many of my symptoms. I'm still learning about MTHFR, and may not be able to confidently express what I know about it. However, One thing I read stated (re the mutated gene), "This is associated with intermediate levels of enzyme activity. . . "
My doctor is giving me Methyl B12, which I can quite surprisingly assimilate. I'm not even getting the jitters. I'm also taking the Methyl form of folic acid (Methyl folate), and doing well with it. From reading on the Deplin site, Deplin is also a form of (or is, Methyl Folate). Even though, Deplin is by prescription, as I understand it, there are apparently other methyl folates out there which aren't in RX form. Perhaps they aren't as strong. ??? Methyl is the form of these B vitamins that helps your body accept them and put them directly to work. Deplin's site gives a good example of how this works.
To sum it up - The reason you may not be able to take antidepressants could be due to a MTHFR Mutation, which could cause you to be short of some B Vitamins which in turn can cause depression, anxiety, nervousness, etc. per my layman's understanding. Only a really good doctor can review your medical history, get some in-depth blood work done, and then determine your best treatment. The MTHFR Mutation is, I believe, a fairly new discovery. A medical doctor who keeps up with new discoveries, and is also open to more natural treatment, when appropriate, i.e., vitamins/minerals vs. prescription drugs, would serve you well. Your doctor sounds on the ball and willing to try new things. Maybe he will investigate the MTHFR Mutation, or he may already know about it
Hang in there. There are answers, and ways to get better. My doctor says he can pull me back to good health and I believe him. I'm headed that way. Hope you will be too.