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Regular Member

Date Joined Aug 2007
Total Posts : 262
   Posted 4/16/2009 9:21 AM (GMT -6)   
I have been thru the ringer trying to find the best anti-depressant for me.  I started taking Zoloft about a week ago and I woke up itching all over with red mouth itches inside...but not swollen....
Has anyone else had this problem with Zoloft?
I am at my wits end trying to find what works best:
Paxil- didn't work much
Lexapro -massive diarrhea
Wellbutrin - totally drugged up, chest pain
Effexor - High BP and terrible stomach cramps
Zoloft- allergic
ANYONE have advice???

Regular Member

Date Joined Mar 2009
Total Posts : 46
   Posted 4/16/2009 4:46 PM (GMT -6)   
man, sorry for your bad luck with meds. I'm on 40 mg of paxil and it does o.k. for me. other than the itching, how do you feel? maybe it will go away after a while. check with your doctor. keep fighting the good fight and hang in there, we have you back:D

getting by
Forum Moderator

Date Joined Sep 2007
Total Posts : 42499
   Posted 4/16/2009 4:57 PM (GMT -6)   
You are like me, you don't tolerate anti depressants well. It took me about eight different tries until I ended up on effexor. I guess that I will have to take it for the rest of my life. I don't like that thought, but I try to just take it one day at a time.

I hope that you find what works for you. Don't give up, there is something out there that you will be able to take. In the meantime, keep us posted.

Hugs, Karen
  Moderator-Depression and fibromyalgia
fibromyalgia, Chronic fatigue, depression,allergies

Veteran Member

Date Joined Mar 2009
Total Posts : 1190
   Posted 4/16/2009 10:19 PM (GMT -6)   
Hi Mom2sophia,

I have the same problems with ADs.....have tried many over the years, and had terrible reactions and side effects as many times, being unable to go to work from being so sick. I finally gave up trying in 2002, after 11 years of trials, and have been using talk therapy and CBT since then. I've hit a real low point with my depression recently, and have just sent off an email to my ND (Naturopathic doc) to request a discussion with her at my next appointment re: alternatives to ADs. I'm hoping she can offer me some good options, since everything else she has prescribed (for other medical problems) over the years has been very effective. I'll let you know how it goes, but in the meantime, I hope so much that you will find something to give you some support and relief. You have my sympathies on your struggle.

Elite Member

Date Joined Mar 2009
Total Posts : 20227
   Posted 4/18/2009 4:40 AM (GMT -6)   
keep tryin' at  the moment pristiq is holding. wish u well, not a fan of zoloft, have clear reasons. i hope u feel better soon, healing light to u, jamie.

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 4/18/2009 6:33 PM (GMT -6)   

Hey there,

You are not alone, I have run the gambit on the AD's also.  I did the best on an old med, Nortriptyline.

Nortriptyline is a second-generation tricyclic antidepressant. I used this medication for years until it finally pooped out on me and I have not found one that worked as well.

Right now I am trying to go without an AD but I know if I need to go back on then I will have to way the pros and cons of each med. 

Don't give up as each person is different.  Cymbalta has worked very well for many.

Keep on talking with us and we will help you through.




Kitt, Co-Moderator:
Co-Moderator Depression

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Not a mental health professional of any kind
Peace does not dwell in outward things, but within the soul
Clickable Link: Anxiety-Panic Resources

Veteran Member

Date Joined Jul 2006
Total Posts : 1257
   Posted 4/19/2009 4:58 PM (GMT -6)   

I take Remeron and have been on it for at least 6 years.  I ran the gamut of a/d meds and this is the one that finally worked for me.  I take it at night because when you first start it makes you sleepy.  Now I don't have that problem.  Keep in mind though that like all other a/d meds this does cause an increase in appetite and I did gain weight on it.  If you are careful you can try to avoid the weight gain but it is not easy.  Hope this suggestion may help you.


Veteran Member

Date Joined Feb 2007
Total Posts : 1050
   Posted 4/20/2009 11:22 AM (GMT -6)   
I also have a huge problem with med allergies. Have to be so careful because so may things can go wrong in me.

I think the only option is, to keep switching until you find a med that actually works and doesn't cause any huge side effects that you don't want.

There are lots of other meds to go through. Lofepramine (Lomont), Remeron and Trazodone. You should speak to your doc to see whats the next best med for you to try.

It's so irritating to have to go through all this hassle though, trying to find something that doesn't cause more problems than what you started with!
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