"Therapeutic Dose"

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New Member

Date Joined Jun 2009
Total Posts : 15
   Posted 6/10/2009 3:52 PM (GMT -6)   
Hey Guys,
I have been on zoloft for almost six weeks.... finishing my third week at 50mg. I have noticed a slight improvement in the depression, but not so much the anxiety. I wanted to try something else, my doctor wants me to keep going up weekly by half a pill (12.5mg). I am getting so frustrated. I feel constantly on edge and have no appetite. When will this get better?
I am 26 and have never had a episode of depression before...i have a wonderful family and boyfriend and job - i have no idea what caused this?
Should i be more patient since i have only been at 50mg for barely three weeks?? I get so confused when some people say you should feel better in 2-4 weeks, and some people add in the "therapeutic" term which i think is different?

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 6/10/2009 4:05 PM (GMT -6)   

Hello there,

The therapeutic range is a statistical concept:  it is the concentration range associated with therapeutic response in the majority of patients.  Consequently, some patients will exhibit such a response at serum levels below the lower limit of the range, while others will require serum levels exceeding the upper limit for therapeutic benefit.

When using AD's some people will do well on a lower dose and others need to be at the higher end to find the drug to be effective.

By slowly increasing the medication you should find a dose that helps you to feel the best you can.  However, due to the lag time of the AD meds being fully effective both the dose and the time on the drug factor into when you will begin to be at the right dose to best meet your needs.

If you are noticing an improvement that is a good sign. You may need another med added to help with the anxiety.  A good one is Buspar for many people.

Keep on talking with us.

Gentle Hugs



Kitt, Co-Moderator:
Depression,  & 
http://www.healingwell.com/donate *~*
"When you find peace within yourself, you become the kind of person who can live at peace with others."
Not a mental health professional of any kind
Clickable Link: Anxiety-Panic Resources

Elite Member

Date Joined Mar 2009
Total Posts : 20279
   Posted 6/11/2009 3:56 AM (GMT -6)   
hi avolleyball, kitt is right, just wanted to lend my support to you. some people will have a single episode of depression, here in australia it is 1 in 5, this may elivate and disappear or it may well become greater. wish you well, take care of you. jamie
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