Hi I'm new to this forum. I'm not sure if anyone can help me but her goes. I have been off work since Jan 2008 due to severe depression. Have tried many Meds-I was on Paxil for 15 years and it pooped out-I was going through a lot of stress at time. I have tried Effexor,Celexa, Lexapro, Lexapro+ wellbutrin, clomiprimine, imiprimine, cymbalta, cymbalta+ lithium, combo Paxil+ wellbrurtin+desprimine, eleven sessions of ECT with little improvement, now Moclobimide( Manerix)-its an MAOI-same family as Nardil, Parnate etc but has less food restrictions. Manerix I don't beleive avail in US. Dr put me on 600mg max dose and went on vacation. First five days were hell-anxiety, breathing diff, hostility, nervousness, chest pain, Went to my psy's backup- reduced dosage to 150mg for a week. Starting dose is really 300mg. I was on 150 mg for 10 days. Still have some side effects, including a bit of chest pain. Doc told me med doesn't really work well until you reach 600mg and we all now that we req at least 4-6 weeks to see if its going to work. Oh-Before my doc went on vacation- he sd we may have to go to 900mg!!. I think he prescribed me 600mg initally because he wants me to get better fast because I have had a hell of a ride since Jan of last year. I just increased dosage to 300mg Monday- I'm trying to get through the increased side effects, even with the chest pain-back up dr dose not think I have a heart prob- that its is prob the existing anxiety or anxiety induced from the drug. He sd he doesn't really know. Well if I didn't have chest pains and incraesed anxiety before starting the drug, would you not think its prob drug induced??
My wife is having a very hard time accepting my depression and being off work for so long- but she doesn't want to go for couples therapy. Does not think they will help us. I have tried to get her to support me, it has been a struggle. I know the stress is effecting my recovery and it is making her mildy depressed also as she has a stressful job also.
Has anyone tried moclobimide(manerix) or an MAOI, and have they experienced serious side effects during inital weeks of treatment? I'm having a difficult time, a have sucidal thoughts and anxiety. Having difficulty just being in same home as my wife and she with me, and having difficulty finding things to do that will help during the day, given that I have to go to another community-because my wife is concerned about it getting back to our community. Anyone? I needed to get this off my chest. Ty