I have been on Effexor since Sept. 2004. I started at 75 mg., then to 150, and finally to 225. I still feel I have a ways to go dealing with my depression and anxiety but my doctor won't up the dosage at this time because my blood pressure has increased - not drastically but enough for her to be cautious. Instead, now I take 150 mg. Effexor at night and one Wellbrutin in the morning. Has anyone else had this combination? Did it work?