Does anyone have any experience with a medication which discontinues working? I have been on 225 mg of effexor and 300mg of wellbutrin for 9 month's with ok results. Saturday everything changed, for no stressful reason that I can think of the med's quit working. My doctor is increasing the wellbutrin to 450 to see if that helps. I have heard of others with med's not working after some amount of time but can it be overnight?