deplin and saphris?!

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New Member

Date Joined Oct 2011
Total Posts : 3
   Posted 10/3/2011 4:58 PM (GMT -6)   
Hi! I'm new to the forum world and would love some feedback on some questions I have...

First of all, I know that I have seasonal depression, but every doctor/ hospital/ therapist keeps throwing around this Bipolar idea. They're the expert, so I believe them.

So, today I was prescribed a few new meds and I'm slightly confused. They are Saphris and Deplin. I am on no other medications at this time... Does anyone have insight or opinion on these drugs? Or possibly how well they work together? I thought Deplin was to enhance other drugs, but I am not on anything!

Thank you for any help!!


getting by
Forum Moderator

Date Joined Sep 2007
Total Posts : 42612
   Posted 10/3/2011 5:49 PM (GMT -6)   
Hello Inmemoryofyou.  This is what I found on your bipolar med.  It is wikipedia definition.  Perhaps the dephlin is to help this work better.
Systematic (IUPAC) name
Clinical data
AHFS/ monograph
MedlinePlus a610015
Pregnancy cat. C(US)
Legal status Rx only
Routes sublingual
Pharmacokinetic data
Bioavailability 35% sublingual
Protein binding 95%
Metabolism hepatic
Half-life 24 hours
Excretion 50% in urine, 40% in feces
CAS number 65576-45-6
ATC code N05AH05
PubChem CID 3036780
IUPHAR ligand 22
ChemSpider 2300725
Chemical data
Formula C17H16ClNO 
Mol. mass 285.77 g/mol
SMILES eMolecules & PubChem

Asenapine (INN, trade names Saphris, Sycrest) is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough after its November 19, 2007 merger with Organon International. Development of the drug, through Phase III trials, began while Organon was still a part of Akzo Nobel.[1] Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain. Over 3000 patients have participated in clinical trials of asenapine, and the FDA accepted the manufacturer's NDA on November 26, 2007 for standard review.[2]

Some American psychiatrists have begun to prescribe the drug to combat veterans with severe PTSD nightmares as an "off-label" use, although this use is not yet allowed by the United States Department of Veterans Administration.

Moderator-Depression and fibromyalgia

fibromyalgia, Chronic fatigue, depression, allergies

Elite Member

Date Joined Mar 2009
Total Posts : 20279
   Posted 10/3/2011 11:54 PM (GMT -6)   
good info karen. cheers. jamie.



New Member

Date Joined Oct 2011
Total Posts : 5
   Posted 10/5/2011 12:07 AM (GMT -6)   
I work with Deplin and I will try to address your question. Deplin is a Prescribed form of the folic acid converted, L-methylfolate, which actually crosses the blood brain barrier (folic acid does not) and this L-methylfolate helps in creating more of the three neurotranmitters. The three neurotransmitters are believed to have something to do with depression, hence the success of SNRIs and SSRIs. Since Deplin is as safe as a vitamin (see Deplin website) you may not have to concern yourself with side effects which may lead to noncompliance. I am not familiar with the other product but if you are depressed, Deplin may help but its indication is an augmentation agent. Let me know if you may have any more questions.

New Member

Date Joined Nov 2011
Total Posts : 3
   Posted 11/29/2011 4:57 PM (GMT -6)   
I was prescribed Deplin today for anxiety..I don't do well with the antidepressants/side-effects he said we should try this..Any feedback is greatly appreciated.
Thank you blush

It's Genetic
Veteran Member

Date Joined Mar 2010
Total Posts : 1540
   Posted 11/29/2011 5:26 PM (GMT -6)   
Deplin (or L-metholfolate) is very beneficial for those who have an inherited inability to metabolize folate from folic acid. Genetic testing is required to determine that, but your physician has prescribed it hoping to see its good effects without the necessity to do genetic testing.

If you have the inability to metabolize folate from folic acid, L-methylfolate is superior to any med I've taken. I would not be without it.

It generally takes two weeks or more to see the effective benefits from it; however, you may begin to feel much more content and happy within days if you do have an inability to convert folic acid into folate (which is the only form the brain can use and it needs folate).

I hope you find it very helpful.


Post Edited (It's Genetic) : 11/29/2011 6:30:58 PM (GMT-7)

New Member

Date Joined Nov 2011
Total Posts : 3
   Posted 11/29/2011 8:28 PM (GMT -6)   
I'm confused on this..why would he prescribe this if I have no issues with folic acid?
thank you.

It's Genetic
Veteran Member

Date Joined Mar 2010
Total Posts : 1540
   Posted 11/29/2011 8:37 PM (GMT -6)   
Hello, Texassaphire,

You would not be aware if your brain does not receive folate from the blood stream unless you have genetic testing.

Doctors are often trying to find the best combination of medications to help the patient to wellness. The use of L-methylfolate is one medication that can cross the blood-brain barrier, so your doctor is hoping that perhaps you might be able to benefit from an increase in folate in the brain (which increases three neurotransmitters: serotonin, dopamine, and norepinephrine all involved in better feeling tone).

It may work, and it may not work for you, just as certain other medications you've taken over the years may have worked or may not have worked. It's your doctor's effort to find the right thing for you.

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