I used to take Zoloft for about a year. I felt better, my life changed, stopped meds. A year or so later, bad life situation happened and I started back on Zoloft but changed to Wellbutrin due to the sexual side effects. I did okay on it for about 2 years, but felt a little zombie-ish. So I stopped it (with Dr. blessing). Now with recurrent depression (no new life event) and anxiety attacks, so back to the doctor for a script of Lexapro. I love it. I've been on it for just over 2 months. I haven't had a full blown anxiety attack, I have energy, I laugh, I feel like I remember feeling a long long time ago. I do have a headache about once a week or so and I am hungry all the time. My doctor and I feel like I will adjust to the appetite thing. I'm already about 40 lbs overweight (that's what chronic depression did for me), so I go to weightwatchers. There is a doctor in my group and she agrees that I will adjust over the next couple of weeks. At any rate, I do not want to stop taking it ever!