can zoloft stop working

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dylan06854
New Member


Date Joined Jan 2012
Total Posts : 3
   Posted 1/8/2012 11:38 AM (GMT -6)   
I've been taking 100mg zoloft for several yrs. I've had bouts of depression & my doc increased my dose to 200mg.
this kept me up until 2:00AM in the morning & I get up a 7:00AM for work. I can't tolerate the increased dose, but, 100mg doesn't seem to be working anymore. Does anyone know if you can get use to zoloft ?? I don't know what to do ??
Or what to switch to.
Any answers would be greatly appreciated.

Crimson Red Scarlet
Regular Member


Date Joined Mar 2011
Total Posts : 117
   Posted 1/8/2012 11:49 AM (GMT -6)   
Hi Dylan,

I'm sorry to hear you suffer from bouts of depression and that the higher dose of Zoloft is not working for you.

Unfortunately, it is entirely possible for and antidepressant to "poop out" and become less effective. This happened to me several years ago with Paxil. You will need to speak to your doctor and see if a change in medication would be advisable; there are many options out there. Also, if you are not already, therapy can be helpful to some.

As to what to switch to, that is up to you and your doctor. Look up both SSRIs and SNRIs and you can find a wealth of info on the net (just stick to reputable sites).

Best of luck,

DarkWolf

bayoub2
Veteran Member


Date Joined Sep 2006
Total Posts : 2861
   Posted 1/8/2012 12:02 PM (GMT -6)   
I took welbutrin for 5 years and then WHAM! it stopped working completely. I saw my doc and heput me on a new med.
Yes anti-ds can stop working for whatever reason. Sometimes an increase will solve problem, sometime you need a new med. Very frustrating

Hope you get back on track soon

Maggie
"We never realize how strong we are, until being strong is the only thing left"
Major Depressive Disorder, ptsd, fibromyalgia, chronic pain, l3/4, L4/5 gone, bursitis arthritis sciatica

seroquel, hydrocodone clonazepam norvasc multi vitamin and magnesium

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 42609
   Posted 1/8/2012 12:17 PM (GMT -6)   
Hi Dylan,

Welcome to the depression forum. I am so glad that you have joined us. I think it is totally possible for a medication to fizzle out after years of taking it, though I have taken one for 15 years and it always worked well. I did switch though because of convenience. I now take pristiq and it works well. I believe it is an ssni. I also take abilify which helps the pristiq work better. It is a mood stabilizer and you may want to talk to your doc about adding one. Or changing meds completely to get some relief from the depression.

Keep posting. You have come to a good place. Know that everybody here cares about you.

Hugs, Karen
Moderator-Depression and fibromyalgia


fibromyalgia, Chronic fatigue, depression, allergies

dylan06854
New Member


Date Joined Jan 2012
Total Posts : 3
   Posted 1/8/2012 12:50 PM (GMT -6)   
Thanks to everyone who responded to my post. It's very difficult to talk to people about depression (even friends) when they've never experienced it. And, finding this forum has been a god sent. I've been feeling depressed for awhile & because I'm on medication, it never occurred to me that the zoloft may have stopped working. which would actually make me feel better not thinking it was me. However, coming off zoloft is another thing. And, after ready several posts about the withdrawal experience, I will be very carful & work closely with my doc. Just want to feel good!! Don't we all !
Thanks again.

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 42609
   Posted 1/8/2012 3:40 PM (GMT -6)   
Make sure you talk to your doc, you may just need an adjustment. Are you on a high dose for zoloft? I took effexor for many years, but did have to increase my dose eventually. I did swith to pristiq and it worked even better for me than the effexor did. I was on the max of effexor too. I also take the mood stabilizer. That might be something that you would want to talk to your doc about too. Adding something. Either way, I hope that you feel better. Keep posting and let us know how you are doing.

Hugs, Karen
Moderator-Depression and fibromyalgia


fibromyalgia, Chronic fatigue, depression, allergies
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