I was on Zoloft for 5 years. It took awhile to kick in and for the first two years it was fairly effective. In fact, I wrote four novels and three novellas during that time, enrolled in college, maintained a good job without problems, and rented a house with my cousin. Adult things! I still had problems however but that is the nature of my illness, it's a hormone thing I believe now so I can't blame the Zoloft. I was also, and this is important, receiving therapy at the time. Antidepressants are a way to jumpstart the healing process. They are not the answer to your problems. If I had realized that five years ago I might not be in my current predicament. Therapy is important. What is more important is lifestyle changes. What is WAY MORE important is changing your way of thinking while the medication is working so that when it stops working you can taper off of it and live a drug free, doctor free life. Cognitive therapy, meditation, keep a thought record... Anyway, after a few years of being on Zoloft it stopped being effective. Only I didn't really realize it. I figured because I wasn't feeling anything, it was working. I still had panic attacks. I didn't really have any desires or hopes or highs. My lows were not too intolerably low. So I stayed on it. Then I started having neurological problems. First just little things like my fingers would go numb and tingly. Over the years it spread up my whole arms. My nose and lips would sometimes go numb. And my legs. I started having tremors and my hands shook alot. I thought I was really sick which made me pretty depressed so the doctors kept upping my Zoloft which made things worse. When symptoms got worse they added new medications until I was on so many drugs that I didn't know what was causing what and was nearly bedridden. It was an awful time. I eventually weened myself off of most everything. Zoloft was the last to go. I'm grateful for the first two years of happiness it gave me but wont be going back anytime soon.