My diagnosis is bipolar and massive panic disorder and OCD. I cycle very rapidly. I take 150 mg Zoloft a day - very little result in 8 years. On July 3, 2012 my doc said "why don't you try this (Deplin), and see how it works, it can't hurt" - and he handed me samples. I noticed a difference within days, taking just 15 mgs a day (one pill). I started to research it and discovered the half life of Deplin (l-methylfolate) is about 3 hours. So, I now spread my dosage out . I take three 15 mg Deplin a day, every 8 hours, 3 times a day, for a total of 45 mgs of Deplin a day. It works, and it has changed my life. Not to be cavalier, but the $$$ cost ($144 a month from Deplin's website) is secondary to me (I too was suicidal for a long, long time). Not suicidal anymore - the cost in $$$ for Deplin is certainly worth my life and certainly worth how much different and better I feel.