Antidepressant not available in US

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Waterfaller
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Date Joined May 2009
Total Posts : 24
   Posted 8/27/2012 7:00 PM (GMT -6)   
I was reading about tianeptine and am really interested in it for it's ability to confer protection from stress induced neurodegeneration and memory problems as well as being generally neuroprotective. I have a lot of cognitive impairment from my depression plus I suffer from a lot of anxiety and don't like taking benzodiazepines. Is it safe to buy a medication from a pharmacy outside of the country? Does anyone know of a reputable pharmacy I might go to? Tianeptine isn't sold in the US - does anyone know why this is? I see papers by US authors in scientific journals describing the merits of tianeptine.


Kathy

Post Edited (Waterfaller) : 8/27/2012 6:06:27 PM (GMT-6)


BnotAfraid
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   Posted 8/27/2012 7:09 PM (GMT -6)   
No idea why it is not available in the US. But you could try a canadian Pharmacy.
Be still and know there is Peace.

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Waterfaller
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Date Joined May 2009
Total Posts : 24
   Posted 8/27/2012 7:14 PM (GMT -6)   
How do you know what you're buying is what they really give you?

getting by
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   Posted 8/27/2012 7:42 PM (GMT -6)   
That is the problem, you don't really know. It is a risk. Myself, I wouldn't do it. But this is your decision. Good luck...

Hugs, Karen

Maybe in time it will be in US...
 
I wanted to put this down as I was not familiar with this medication and I am sure that there are others who aren't.  This way we can learn about it..
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701287/
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Post Edited (getting by) : 8/27/2012 6:46:39 PM (GMT-6)


BnotAfraid
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   Posted 8/27/2012 7:43 PM (GMT -6)   
Pharmacist Oath? I don't know. I never bought out of the country. Will have to wait and see if any of the other members have.
Be still and know there is Peace.

Kabir says: "Student tell me, what is God? He is the breath inside the breath". from the poem Breath.
DX: reverse Trigeminal Neuralgia;Cluster headaches; Atypical face pain; raynauds;complex PTSD; recurring MDD,disassociative disorder;

Waterfaller
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Date Joined May 2009
Total Posts : 24
   Posted 8/27/2012 10:52 PM (GMT -6)   
I also noticed that it uses the glutamate system which has been getting a lot of attention in antidepressant drug development lately.

Thanks Karen, for posting the link to that article. I had read the article but wasn't sure it was ok to post the link. Am I right that I would have had to check with administrators first?

Kathy

jujub
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Date Joined Mar 2003
Total Posts : 10407
   Posted 8/27/2012 11:31 PM (GMT -6)   
As to why it isn't available in the US, here is one explanation. Not familiar with the journal, I found this on a Google search:
 
Online forum users are quick to wonder why tianeptine hasn’t reached American markets, if it seems to work as well as conventional antidepressants, apparently has fewer side effects, and has been approved in much of Europe, Latin America, and Southeast Asia. In the United States, the intricacies of international patent law have made it financially difficult for tianeptine to get FDA approval. Tianeptine is decades old, but it wasn’t until the late ‘80s and ‘90s that its antidepressant effects were discovered. Tianeptine is now off-patent, meaning that if Servier were to get the drug approved, any company could make and market the drug on their ticket. Given this, it isn’t financially worth it for Servier, or any other company, to sponsor the FDA clinical trials required for drug approval. It’s worth noting that it may be possible for tianeptine to be repatented with a different use in mind, such as irritable bowel syndrome. If this were the case, it would be lucrative for a company to sponsor its FDA application and tianeptine could be prescribed off-label for depression in the United States.
 
http://hypocritereader.com/13/antidepressants
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getting by
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Date Joined Sep 2007
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   Posted 8/28/2012 4:55 AM (GMT -6)   
You can post links to articles as long as it isn't a site selling something.

Thanks Judy for posting this and the link.

Hugs to all,

Karen...
Moderator-Depression and fibromyalgia


fibromyalgia, Chronic fatigue, depression, allergies

Waterfaller
Regular Member


Date Joined May 2009
Total Posts : 24
   Posted 8/28/2012 3:00 PM (GMT -6)   
Judy2 said...
As to why it isn't available in the US, here is one explanation. Not familiar with the journal, I found this on a Google search:
Online forum users are quick to wonder why tianeptine hasn’t reached American
markets, if it seems to work as well as conventional antidepressants, apparently
has fewer side effects, and has been approved in much of Europe, Latin America,
and Southeast Asia. In the United States, the intricacies of international
patent law have made it financially difficult for tianeptine to get FDA
approval. Tianeptine is decades old, but it wasn’t until the late ‘80s and ‘90s
that its antidepressant effects were discovered. Tianeptine is now off-patent,
meaning that if Servier were to get the drug approved, any company could make
and market the drug on their ticket. Given this, it isn’t financially worth it
for Servier, or any other company, to sponsor the FDA clinical trials required
for drug approval. It’s worth noting that it may be possible for tianeptine to
be repatented with a different use in mind, such as
irritable]<i>. If
this were the case, it would be lucrative for a company to sponsor its FDA
application and tianeptine could be prescribed off-label for depression in the
United States.

http://hypocritereader.com/13/antidepressants


Thanks for posting that Judy. That's really frustrating. I doubt it will ever be sold here. I may try to buy it online from Canada.

Kathy

CailinGaelach
Regular Member


Date Joined Mar 2012
Total Posts : 37
   Posted 9/10/2012 3:06 PM (GMT -6)   
[quote=Thanks for posting that Judy. That's really frustrating. I doubt it will ever be sold here. I may try to buy it online from Canada.

Kathy/quote]


Careful, Kathy. As far as I know, it's not legally sold in Canada, either, so anything you get from those Canadian online pharmacies can be sketchy, unfortunately. There are legitimate pharmacies, but sadly, recently there have been a glut of dodgy ones selling counterfeit drugs produced in China and the like. ...I'm Canadian, but I'm going to ask my doc about Tianeptine, myself. Sounds like a fabulous medication on many levels.

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