I have been on Zoloft for about 5 years now and I feel like the effects of the medicine have begun to wear off. I am on 100mg a day, I recently had a baby 6 months ago and was taking this Zoloft while I was pregnant. My baby is happy and healthy, no side effects from the medicine (which I was extremely worried about). My problem now is about 2 months ago I feel like the medicine is not working the way it should or was when I first was on it up til 2 months ago. Im not sure if the effects of Zoloft wear off after a certain amount of time. My anxiety is back and I am a roller coaster of emotions everyday. I am very happy with my baby and the man who im seeing (who is very supportive and is concerned for my health) Has anyone else had this problem or know of any solutions? Please help!