Hi All - Have been taking remeron on and off for a number of years now. Will always gain some weight although it stays somewhat under control with also taking zantac. Researchers have actually done a study on using zantac along with meds that act on the histamine receptors and make you gain weight; and it does work, but you also have to take a lot of zantac. My problem is the constipation. Even with upping the flax seeds, bran and all the other natural methods it is still a problem. I have read of some individuals using cholinergic meds such as galantamine to undue to anticholinergic constipation. Anyone know anything about this. Also, those of you who are taking remeron 7.5 mg every second day - do you find the side effects a lot less.