Experiences with Cymbalta

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New Member

Date Joined Sep 2016
Total Posts : 15
   Posted 3/3/2017 1:00 PM (GMT -7)   
Hello Everyone-

I recently went medication free for 5 months after 17 years of taking an SSRI. The withdrawals were a nightmare but once I got through them I was so proud of myself for coming so far. It was a grueling two months of horrible withdrawal as I went through the wean process. Then for the past 3 months it has been a matter of coping and adjusting to dealing with my ever so hectic life without the assistance of medication.

Unfortunately I am having a hard time coping off of the medication with so much going on in my life right now. I decided that I needed to get back on some type of medication since my daily quality of life has been diminished because my days have been riddled with racy thoughts, stress, worry, and anger recently and my OCD has magnified X10 since being off the medication. With this being said, I didn't want to go through a gamut of trying numerous medications to find the one that works best for me. There is a new Genetic Testing that some Psychiatrist offices offer now and mine is one of them. I completed the testing and the results showed that the best family of medications that would work for my genetic make-up is SNRI's. So, three days ago, after 5 months of being medication free, I started on 30mg of Cymbalta. I do know that there are side affects to get through before knowing for sure if this medication will work for me. I do have some of the side affects already and am hoping they will pass. I have no experience at all with SNRI's I have only ever been on SSRI's with the exception of an Ativan on the rare occasion that I need to take one. I seldom do as I do not care for the way Benzodiazepines make me feel.

I am wondering if anyone can give me their input on any experiences they may have had with Cymbalta.

getting by
Forum Moderator

Date Joined Sep 2007
Total Posts : 42075
   Posted 3/3/2017 1:57 PM (GMT -7)   
I am not taking Cymbalta, but I have taken Effexor and now am on pristiq. I didn't really have side effects with the snri's. Serotonin, norephenephrin, reuptake inhibitor. I know I spelled that wrong, but they have an antianxiety property that helps a lot. They can also help with pain if you have it, especially the Cymbalta from what I have read. What type of side effects are you having?

I hope that the Cymbalta works for you. Remember it takes six to eight weeks to reach full potential. Though I always find myself feeling better before that.

Maybe if you could cut your Ativan in half or something, it might not make you feel as bad. I was thinking maybe you needed a lesser dose for it to just relieve anxiety and not make you feel sleepy or what ever is happening.

We do have members here who have been on Cymbalta and hopefully they can give you some information.

Keep posting, it helps.

Hugs, Karen...

fibromyalgia, Chronic fatigue, depression, allergies

Myself 09
Veteran Member

Date Joined Dec 2009
Total Posts : 6145
   Posted 3/3/2017 3:55 PM (GMT -7)   
I did not do well on Cymbalta. It was originally prescribed for pain/fibro. It did nothing--and made me furiously angry. I stayed on for seven months to give it good test, then started weaning down with doctor's supervision.

All medications have side effects: Good ones (the reason we are taking the med) and bad ones. If the bad outweigh the good ones, then talk to the doctor.

One suggestion--many people have to make their peace with long-term, life-long medication use. We don't have to like it, but we do need to recognize that us with medication is better than us without.

New Member

Date Joined Apr 2017
Total Posts : 2
   Posted 4/28/2017 5:33 PM (GMT -7)   
I understand your reluctance to meds. I have struggled with depression/anxiety my adult life and have always been resistant to taking meds thinking I should be mentally strong and get through this myself.. I have taken numerous ones over the years for a few months at a time and had no affect. Now I am still reluctant to try new ones.

Regular Member

Date Joined Apr 2017
Total Posts : 462
   Posted 5/2/2017 12:48 AM (GMT -7)   
Personally I have no experience with Cymbalta but did some research on it as I was hoping to be Rx'd Cymbalta for my OA pain. I had a severe leg injury over a decade ago and have been taking Tramadol ever since. Three years ago I developed prostate cancer and am now on ADT hormone therapy which causes mood swings and lots of hot flashes. Gabapentin helps the hot flashes but am supposed to start Effexor in a couple weeks as that will maybe handle the flashes better but also handle the mood swings.

I've never taken any mood altering drugs before (well, okay Tramadol being a narcotic does that somewhat). I had to taper off the Tramadol because it would interact with either the Effoxor or Cymbalta... it's called serotonin syndrome. The opiate discontinuation was difficult but actually the Gabapentin helped settle the limb restlessness. I have more surgery in two weeks and will start the SNRI (Effexor) afterwards.

My wife kept telling me that I was depressed following a traumatic experience a couple years ago but I was having trouble getting help. I seem so stable to most. But with my family I would just fly off the handle so to speak and end up sulking for weeks. Somewhat difficult to explain. Then just a few months ago we discovered that my wife has stage 4 lymphoma. Her large family came to visit in the hospital and I really lost it. That's when everyone was telling me to get some help.

So anyway that's what led me to Effexor... my cancer and SE's from therapy, her cancer and me now a caregiver... on top of chronic OA pain. So that's what led me to Cymbalta, end eventually to Effexor. This is going to be a new experience for me and I feel better just knowing that I will finally be getting treatment.
2014-15: PSA 9,12,20,25 Neg DRE, Neg TRUS biopsy
2016: MRI Fusion biopsy, Rt Base, 2x 100% G8 (4+4)
8/16: DaVinci RP, PNE, 6mm EPE, 2xSVI, pT3b N0M0
2017: Lupron ADT, AMS800 AUS scheduled 5/15/2017
IMRT SRT postponed til that heals, PSA's ~.03
Age 66, recently retired to Florida 'just in time'
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