Personally I have no experience with Cymbalta but did some research on it as I was hoping to be Rx'd Cymbalta for my OA pain. I had a severe leg injury over a decade ago and have been taking Tramadol ever since. Three years ago I developed prostate cancer and am now on ADT hormone therapy which causes mood swings and lots of hot flashes. Gabapentin helps the hot flashes but am supposed to start Effexor in a couple weeks as that will maybe handle the flashes better but also handle the mood swings.
I've never taken any mood altering drugs before (well, okay Tramadol being a narcotic does that somewhat). I had to taper off the Tramadol because it would interact with either the Effoxor or Cymbalta... it's called serotonin syndrome. The opiate discontinuation was difficult but actually the Gabapentin helped settle the limb restlessness. I have more surgery in two weeks and will start the SNRI (Effexor) afterwards.
My wife kept telling me that I was depressed following a traumatic experience a couple years ago but I was having trouble getting help. I seem so stable to most. But with my family I would just fly off the handle so to speak and end up sulking for weeks. Somewhat difficult to explain. Then just a few months ago we discovered that my wife has stage 4 lymphoma. Her large family came to visit in the hospital and I really lost it. That's when everyone was telling me to get some help.
So anyway that's what led me to Effexor... my cancer and SE's from therapy, her cancer and me now a caregiver... on top of chronic OA pain. So that's what led me to Cymbalta, end eventually to Effexor. This is going to be a new experience for me and I feel better just knowing that I will finally be getting treatment.
2014-15: PSA 9,12,20,25 Neg DRE, Neg TRUS biopsy
2016: MRI Fusion biopsy, Rt Base, 2x 100% G8 (4+4)
8/16: DaVinci RP, PNE, 6mm EPE, 2xSVI, pT3b N0M0
2017: Lupron ADT, AMS800 AUS scheduled 5/15/2017
IMRT SRT postponed til that heals, PSA's ~.03
Age 66, recently retired to Florida 'just in time'