Weak LES from Effexor

Vaajurooby

Regular Member

Joined : Apr 2018

Posts : 43

Posted 6/20/2018 7:22 AM (GMT -7)

Hi all..
I have been on Venlafaxine 150 for 3years and it has made my LES weak and it's not closing properly.. I have developed Gerd and because of this I'm much anxious and depressed.. Has anyone had such a rare experience??

NiceCupOfTea

Elite Member

Joined : Jan 2010

Posts : 10674

Posted 6/20/2018 8:56 AM (GMT -7)

What makes you sure it's the venlafaxine after 3 years? I'm stating the obvious here, but speak to your doctor if you haven't already. You could always try switching to another antidepressant to see if that makes a difference. Good luck. GI symptoms can be pretty miserable, so I hope you can resolve it.

Dx Crohn's in June 2000. (Yay

)
Tried: 5-ASAs, azathioprine, 6MP, Remicade, methotrexate, Humira, diets.
1st surgery 20/2/13 - subtotal colectomy with end ileostomy.
2nd surgery 10/7/15 - ileorectal anastomosis. Stoma reversed and ileum connected to the rectum.
Current status: Chronic flare. Do I have any other kind?
Current meds: 50mg 6MP; Entyvio (started 3/11/16)

Vaajurooby

Regular Member

Joined : Apr 2018

Posts : 43

Posted 6/20/2018 9:26 AM (GMT -7)

I'm sure it's Venlafaxine, bcs there s no other reason for my LES to be weak.

BnotAfraid

Forum Moderator

Joined : Apr 2012

Posts : 7570

Posted 6/21/2018 2:12 PM (GMT -7)

Call the docs office ASAP and discuss this, they may want to wean you off and start another med.

Don't wait, and you are not bothering them, they are your care giver.

Peace
Trina

Moderator - Depression

"...when the gift of sight is cause enough for jubilation."
Billy Collins from the poem. HIGH

DX: reverse Trigeminal Neuralgia;Cluster headaches; Atypical face pain;Hemicrania Continua; raynauds;complex PTSD; recurring MDD,disassociative disorder;

RobLee

Veteran Member

Joined : Apr 2017

Posts : 994

Posted 7/7/2018 11:49 AM (GMT -7)

My GERD and LES insufficiency began a decade before starting Venlafaxine. I blamed it on Naproxen, but it could have been just normal aging. No one ever knows these things. I do know that GI distress is the most common SE from Effexor, but if you are taking the ER/XR form and taking it with food and able to sit upright after taking it, then it should not be a problem. I'd had Barrett's esophagus long before starting any A/D and things like onions cause more problems than does the 150mg/day of Effexor.

Changing to a different drug MAY improve your condition for now, but I suspect you'll be experiencing it a lot more in the future.

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