Hi Els and Bluemeanies, thanks for your quick responses. I just went from 30mg to 45mg but was saddened that the 15mg and the 30mg did not last very long (only a few short months). I am hoping that the 45mg will last a bit longer. Els, do you know if your friend takes a 45mg tablet and then a 15mg tablet? I don't know if Remeron makes a 60mg tablet..just curious. Bluemeanies, I am feeling better knowing that someone has been on the 45mg for three years..that is a long time for an antidepressant! I have heard of stories where antidepressants poop out rather quickly. I am hoping that won't be the case..because it took so long for me to find something that works. I tried all the SSRI's and had such bad side effects..and was very lucky to be prescribed Remeron while hospitalized..it gave me no side effects (except some weight gain and increased hunger)....very good antidepressant!