I used to take SAM-e. It is a little on the pricey side but worth it. You can get coupons for $7.00 of on each purchase on the SAM-e dot com website. You can purchase it in the Supplement isle in grocery stores, drug stores or Health food stores. The Nature Made brand is very good. I have had major/clinical depression most of my life and took it for three years and was depression free. I started on 200mg for about
a week and then went to 400mg - once a day on an empty stomach.
If you would like more information you can go to the SAM-e dot com website and it will give you more information or you can "google" SAM-e. It is documented in many well respected and scientific medical/Psychology journals for depression and considered very safe. It is an amino acid that is naturally produced in our bodies, that we don't get enough of in our diets or that can decline as we age. It was first used as a Prescription in Europe for depression and it came over to the states in the early 90's.