Zoloft has worked for me but only to an extent. What has helped me the most is to get out there, do volunteer work, exercise, eat healthy, rest. I find I am not so all alone but it is tough to try to stay motivated. I have vegetative depression which means all I want to do is sleep and eat...escape through tv, books, videos, etc. I also have a lot of other health problems too. The boards have also helped me.