Hi Bethers,welcome to HW. I've been taking zoloft for about 15 yrs. I started out with 50mgs. I took that for years. After I found out I was ill(another story) they put me on 100 mgs. I didn't like how they made me feel (jittery and more anxious) so I took 75 mgs by taking 1 50mg and breaking the other one in half. Now I'm back on the 100mgs and I'm doing alot better. I think it's best to talk to your Dr. about what works best for you. I was very lucky, I didn't have too many side effects. but they should go away after your system gets used to taking them. I definately see a difference taking 100 mgs compared to 75. It just takes a while for them to work and for you to see a change in how you feel. I don't know why they were too much for me the first time i started taking the 100 mgs. I think alot of it has to do with what is going on in your life at the time. I wish you all the luck! I hope you get the dosage that works best for you. Take Care!