Back to meds - which one to try next?!

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Regular Member

Date Joined May 2006
Total Posts : 45
   Posted 12/8/2006 5:11 PM (GMT -6)   
Hey everyone,
I originally joined Healing Well because I have Ulcerative Colitis but now I need advice from this forum too,... hopefully you can help :)
I've been treated for depression for the past 10 years (since I was a teenager but some docs think it started when I was 10 or 11). I'm pretty sure it's unipolar and I may have a cyclothymic personality too, I was also treated for generalised anxiety disorder, OCD, agoraphobia and eating disorders.
After a few years of counselling, hypnotherapy and psychiatrist visits I was started on anti-depressants. The 1st one was Seroxat. It didn't do much good and my dose was continually increased for 3 years. In the 4th year my docs added Zyprexa to the mix. A year later I was still severely depressed (and fatter!) and suicidal. Thankfully my good friend is a GP and when I told her about my treatment she advised me to ask docs about new meds. So I came off Seroxat and started on Effexor XL. I had a really, really hard time coming off the Seroxat! The Effexor worked really well for about a year and I was on it for about 2 years altogether. I've been off meds for almost 2 years now but I've been feeling depressed again since early this year.
My latest bout of depression is nowhere near as bad as when I was younger, I think it came on because of stress, my current lifestyle situation and the dark, miserable winter days. I tried CBT this year and although I found it to be really good regarding my confidence and self-esteem it hasn't helped with the feelings of hopelessness, crying, tiredness, poor sleep and the general feeling that everything is a major effort. So my GP friend has recommended that I try meds again, at least over the winter. She suggests that I try the newer ones like Cymbalta or Citalapram. I was so proud of myself getting off the meds in the 1st place that this feels like a step backwards, but it would be preferable to ending up severely depressed again (I think that scares me more than anything!).
Sorry about the lengthy rant here ;) but if you think you can advise me at all regarding good meds (preferably without TOO MANY side effects!) then I would be most grateful to hear your thoughts.
Thanks in advance :)

Veteran Member

Date Joined Apr 2004
Total Posts : 2284
   Posted 12/9/2006 8:26 PM (GMT -6)   
It is perfectly normal to have depression accompanied with a chronic illness. Hang in there. I found it took several tries at anti-d meds before I found one that worked well for me. Good luck and I hope you find the answers you are looking for.
We can respond to irritation with a smile instead of scowl, or by giving warm praise instead of icy indifference. By our being understanding instead of abrupt, others, in turn, may decide to hold on a little longer rather than to give way. Love, patience, and meekness can be just as contagious as rudeness and crudeness.


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Veteran Member

Date Joined Aug 2005
Total Posts : 617
   Posted 12/12/2006 12:25 AM (GMT -6)   

Hey Suesse,

I've been taking meds for depression, anxiety and panic disorder for about eight years now.  I've tried pretty much all medications available for these dxs.  I also suffer from chronic migraines, degeration and arthritis in my spine, and bad knees.  Plus, I'm in the process of having all my teeth fixed, due to the dry mouth I got while taking Depakote.

Right now I'm taking a cocktail of Cymbalta, Klonopin, and Wellbutrin.  Wellbutrin might be a good choice for you, as it is an "activating" medication, as it allows you to feel motivated.  It does have some side effects, all of which I consider good, like it helps you to loose weight or quit smoking.

Talk to your doctor and see if Wellbutrin might help you.  Good Luck and let us know how you are doing.

Leigh Ann cool

"The weather is here, I wish you were beautiful."
                                             - Jimmy Buffett

Veteran Member

Date Joined Dec 2006
Total Posts : 517
   Posted 12/14/2006 10:27 PM (GMT -6)   
Suesse -

I was pretty recently diagnosed with UC, and have also been taking anti-deps for a long time. I've tried so many pills in my time that I can't even remember some of them. The ones that I know helped me the most were either Prozac or Wellbutrin. Unfortunately, since my UC diagnosis, I've been going downhill without my knowledge. I don't know if you're UC has thrown you for a loop like mine did, but I'm still trying to get my life back under control. Good luck with the med search. If you find a good one, let us know.

Regular Member

Date Joined Aug 2006
Total Posts : 60
   Posted 12/16/2006 10:42 AM (GMT -6)   
hiya there , i suffer from depression too . have been on so many different medication for it . some has worked and some has not . whatever you do , don't try escitalopram . it is a very potent ssri antidepressant drug . it is one of the newer ones . it was too strong for me . it made me more depressed and very suicidal . i recommend seroxat [ paroxtine ] . was on it for 5 years before it stopped working . whatever you choose , hope it works for you . good luck :-)

Regular Member

Date Joined May 2006
Total Posts : 45
   Posted 1/26/2008 11:09 PM (GMT -6)   
Hey, I just returned to Healing Well after a LONG absence because of issues with my UC but.... my depression is totally under control for the past year. I tried the Cymbalta and I'm still taking it. The side-efects for the first few weeks were pretty horrendous but they're gone now and I feel great (apart from my UC! D'oh.)

So after approximately 18 years of depression and 11 years of anti-depressants I would now recommend a combination of CBT and Cymbalta :-)

Take care x

Veteran Member

Date Joined Jan 2006
Total Posts : 2408
   Posted 1/27/2008 7:29 AM (GMT -6)   

Im glad to hear that everything is under control and that you are getting on with your life. Hopefully the UC will fall into line soon as well! I have my fingers crossed for you!


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