Hey Vic, As you know I take Effexor Xr. When I was started on it, it was for depression and also because it does have the side effect of Hypertension. I have that autonomic disorder that causes me to have really low blood pressures. When I got to the dosage of 150 mg on the Effexor depression wise I was stable but my BP's still sucked. So my Psychiatrist kept increasing until I reached 225mg. My Syncope episopes have been fewer then before so it is helping in that area for me in combination with my other medications I take for my blood pressure. It can also cause rapid heart rates...however, I have a pacemaker due to bardycardia so my heart is regulated by the pacer.