Thanks so much for replying. It is good and reassuring to know that there is someone out there. Since late teens I have had recurring bouts of depression but didn't know what it was as it felt mostly like anxiety. Up until several episodes ago I was prescribed prothiaden which had moderate results. Then my doc changed me to effexor and I thought I had found the miracle drug as it worked really well during my last few episodes. I was on a maintenance dose of 75mg but was advised by a phychiatrist to stop taking the maintenance dose of antidepressant as he prefers mood stabilisers. I only lasted about 3 months off my meds but then for the first time felt myself getting high, not very manic but certainly more creative, talkative, outgoing, confrontational than I would normally be. Hence the Lithium. My doc started me on Lithium and when the slide into depression started increased the lithium rather than start me back on effexor. I then went back onto effexor + lithium. The lithium was a nightmare as I probably didn't need it but it also seems to have slowed down the effectiveness of the effexor. I am now 4 and half months into this episode with up and downs. I would normally be weaning off back to my maintenace dose by now. I feel like I am getting nowhere.