Some really good answers here. My GF has suffered from depression that requires meds for about 20 years now. She has tried (in order) Prozac, Celexa, Effexor and Wellbutrin. For the first three, she functioned OK for a while, but the drug seemed to lose its intended effect after a period of time (sounds like a common occurrence). She is taking Wellbutrin (75mg) now and it is almost having no effect after 2 months. This roller-coaster ride is wearing on our relationship. She started taking Wellbutrin because we have had zero sex life for the past 6 years, and she thought it might help. We are both looking for answers, but there doesn't seem to many available. Any insight or information would be helpful. Thank you in advance.