Hi : I am new to the forum, but have been dealing with depression for the past 13 years. I first took prozac in 1994, the a few years later went on to zoloft. I am in counseling and the therapist suggested I see a group which deals solely with medication issues. There is a psychiatrist and specially trained nurse practitioners. Anyway, went from Zoloft 150 to 200 (max daily dose) because I was having difficulty getting out of bed; constantly feeling blue, etc. Anyway, the 200mg. has made me agitated and irritable, and diarrhea..isn't that nice? So anyay, the practitioner said if the 200 of zoloft failed I would switch to cymbalta. Has anyone been through this? Feeling alone and like a loser today.