Hi Lucy, I have been taking Cymbalta and Oxycontin for several years and have no trouble with combining the two. I can't say the Cymbalta has worked any miracles for my depression, but I think it has helped some. It's hard to know what is working for me because I am in such a constantly stressful situation, trying to help my son recover from alcoholism....and financial problems.....and I don't sleep well because of RLS, PLMD and sleep apnea. I don't know if you should take Cymbalta just to help with your pain because I cannot say that it has helped mine any. You are quite right to be careful about
adding more medications to your list if you don't really need to. Good luck to you, Hon......I hope you begin to feel better soon.