I also have Crohns and have been on Cymbalta for a little over 5 weeks. I believe the meds have helped me. I'm not 100% but I'm doing alot better than I was without it. I have not experienced the weight gain as of yet, however, I have experienced the lack of sex drive. All in all, I cannot complain, as it seems to be working. The doctors told me that it takes 4 to 6 weeks for it to fully take affect, so hopefully it work even better for me in the next few weeks. I'm currently on 90 miligrams, don't be alarmed, I'm also 6'6" and weigh 275 pounds, my doctor said that I need that much of a dose for a guy my size.