Endogenous Anxious Depression - Tricyclics

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Regular Member

Date Joined Nov 2007
Total Posts : 146
   Posted 12/2/2007 12:38 PM (GMT -6)   
Hi all,
I posted a while ago complaining of severe insomnia.  I think I have come to terms with myself that I have many other symptoms of depression and am simply not in control of them.  BIG revalation!  I have been an a sleep deprived anxious emotional roller coaster the past few weeks and am finally comming to terms with the fact that this is brain chemistry, and not something I can fix on my own.  My mother and brother also have these issues...but ya know ya never think it will happen to you!
So I think I had mentioned that I had a horrible exp with Zoloft.  In my research I learned that people who have "Anxious Depression" and severe insomnia etc actually benefit more from the older Tri-Cyclics, because they are more sedating, where ther SSRI's are stimulating which is NOT what someone who also has anxiety issues needs.  We are wired man!  :) I guess I always envisoned depression as feeling constantly sad, laying around, no motivation.  But I felt like I wanted to enjoy my life, and should be but just could not because I never felt "right".  I have diagnosed myself with all possible medical conditions but am healthy as a horse, but seem to have some mixed up neuro-transmitters (Thanks Mom and Dad! :)
So I took Doxepin (Sinequan) for a few days a couple of weeks ago and quit because it made me dopey.  And of course all my symptoms continued, to the point where I was crying at anything and not understanding what was wrong with me.  So I am giving it another go, and it is helping me sleep but boy do I feel SPACEY!!  I am interested to hear others exp with TCA's.  I know they are not commonly prescribed, but I think I have a better shot with this type of drug than an SSRI.
Sorry for the novel :)  Thanks for reading if you got to the end...I also have hyper-graphia...I like to write.  :)

Another Day
Veteran Member

Date Joined Mar 2007
Total Posts : 1055
   Posted 12/2/2007 4:40 PM (GMT -6)   
Welcome to HealingWell,
I wish there was something I could say to help you, but I have to admit I don't know anything about endogenous anxious depression.  I did want to stop in to welcome you until someone else comes along who might be able to help you.
Take care!

Moderator, Allergies/Asthma
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Epilepsy, asthma, GERD, depression, hypothyroidism, tinnitus

Veteran Member

Date Joined Oct 2005
Total Posts : 4031
   Posted 12/2/2007 8:18 PM (GMT -6)   

Hi BG1, Welcome to healing well and the depression forum. 

I hope you do give your medication a fighting chance this time around.  It is true that often doctors have to change medications, dosages, or even stacking antidepressants together to get the best desired result.  Everyone is different and reacts different to all these meds. 

I have major depression, post traumatic stress disorder, and anxiety/panic disorder.  It literally took years for me to find an medication that I wasnt all dopey on.  I take Effexor Xr for the depression and use Xanax as needed for the anxiety.  I dont recall being on any one antidepressant and it helping with both disorders.  But of course everyone is different...

Here are a few links on this topic.  Take care


Regular Member

Date Joined Nov 2007
Total Posts : 146
   Posted 12/3/2007 6:35 PM (GMT -6)   
That was a great article, especially the second one. Since this is an anonomyus site, I can say I work in the pharmaceutical industry, specfically in pharmacology research (how Ironic) Mechanisms of action are never completly understood, for what I do "The proof is in the Pudding" so to speak, if a compound alleviated disease, it is effacacious. The curious thing with SSRI's is that the drug works from day one, chemically, but it takes 4-6 weeks for the patient to feel better, this is the puzzeling thing. Also that placebo has 80% of the effect of SSRI and exercise has proven to be just as good, which is what my Dr. has been telling me. These are just thoughts. Thanks for the articles, I really enjoyed them.
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