Byetta 10 is making me sooo sick!

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New Member

Date Joined May 2006
Total Posts : 2
   Posted 5/26/2006 1:19 AM (GMT -7)   
I have taken Byetta for 2 mo. Just last week the docter moved my up to the10 pen even though I told her the 5 pen made me sick. Now when I take it I am so ill I am in bed and cannot even move.
I am wondering if it will ever get better. I do not lik the feeling. I have lost 15 lbs. would have liked more, I do try to walk 2 miles when I am feeling ok usually before I have to take the next shot.
I am down for a good 3-4 after morning shot.
I go weigh myself tomorrow and will see if I can get some anti nausea help from here. How long does it take to get rid of the yuk feeling.
I get so tired, jittery, a low surgar feeling, but do not have diabetes I am pre diabetic, with insulin resistance.
Suggestions would be greatly appreciated!

New Member

Date Joined Jun 2006
Total Posts : 2
   Posted 6/2/2006 6:55 PM (GMT -7)   
i've used byetta for several months w/ pretty good results.
here's a few things i've learned.
take the injection, and try to eat a small meal fairly soon (within 15-20 minutes). If I wait for 45 minutes or 1 hour I get really sick.
A few nice diiners with my wife have been ruined.

In the morning I take my oral meds first and then maybe 1/2 hour later (after shave and shower etc) I take the byetta, and then have a protein shake ( for diabetics-presc. by my doctor). I find a big breakfast makes me feel very uncomfortable. My wife always has oatmeal in the morning, and just a few spoons. of that seem to be very easy on my stomach.
If I feel queasy one of the best things to do is sit in achair, with my back straight, and do deep breathing, slowly, purposefully. It seems to help my stomach settle down, and the other thing is to walk. If I feel nauseous I try to just walk until things settle down.

A friend of mine found that eating a little more carbs ( like oatmeal) or 1 piece of whole grain toast helped settle her nausea alot. She also found the walking a great help and now walks to work almost every day.

good luck, paul v

Veteran Member

Date Joined Oct 2005
Total Posts : 534
   Posted 6/2/2006 8:33 PM (GMT -7)   
Hi Tracy,
What in the world is your doctor thinking????  You were sick on the 5mcg pen and never got rid of the nausea and he moved you to the 10 mcg pen AND YOU'RE NOT EVEN DIABETIC????  I've got news for your doctor, there are lottsa oral meds out there that will help a pre-diabetic at least as well as Byetta.  And incidently, Byetta is not a prescription for weight loss, just ask tracy if the nausea is worth it!
Yes tracy, your jittery feeling is probably low blood sugar.  Byetta can and will do this to you if you are not careful about what you eat and the doses that you take.  Again, if your numbers are only "pre-diabetic" I really question why your doctor put you on something as brutal as Byetta, especially 10mcg. (brutal from the nausea/blood sugar lowering standpoint).
I am a Byetta user and I'm very lucky in that I've really not had to cope with the nausea, but as for the effect that the Byetta has... well, with out the Byetta I will run 250-350 for blood sugar.  With the 10mcg pen and 500mg of metformin and 5mg of Glipizide I run 80-100.  I use this example to show how powerful this drug really is, and it should not be prescribed lightly. 
Tracy, eventually the nausea goes away, but maybe before you get to that point, you should ask your doctor, and I hope he is an endocrinologist, why your are on Byetta (particularly 10mcg) as a pre-diabetic and not simply an avandamet or some such equivalent oral treatment?
scool  Warren
It's not that some people have willpower and some don't. It's that some people are ready to change and others are not. - James Gordon, M.D.
What some call health, if purchased by perpetual anxiety about diet, isn't much better than tedious disease. - George Dennison Prentice

I can only please one person per day, today is not your day...tomorrow doesn't look good either.

New Member

Date Joined Jun 2006
Total Posts : 1
   Posted 6/3/2006 12:28 PM (GMT -7)   
I have been a Type 2 diabetic for a number of years. I have had a hard time losing weight. My BS has never been in the 80 - 90 range during the years taking 2 different medications. about 5 months ago my doctor put me on Byetta at 5mcg and immediately I not only felt better but my numbers were manageable. One month later he moved me to 10mcg and within the first month I lost 10 pounds and felt better. My one side effect was nausea. Not much though. The second and third month I was at a plateau and remained at a steady weight. In month 5 I have now lost another 5 lbs and I do feel and look better. My biggest problem right now is the nausea. What I need to know is what are people doing with the nausea? I am looking at what types of food am I eating. I found that if I had my cereal in the morning with milk I was worse than if I didn't drink the milk I put on my cereal. The other day I even brought stuff up. I don't want to quit. I just want to feel better.

New Member

Date Joined May 2006
Total Posts : 18
   Posted 6/12/2006 7:45 AM (GMT -7)   


Sometimes I think it is what you eat and how long you wait after the shot.  I have found that I can't eat eggs in the morning anymore. I do eat tums and sip ginger ale, Canada Dry has a diet Cranberry Ginger-Ale that is very good.  I also put a cold cloth on my throat.  You may want to keep a food/shot log and that way you can look back and see if there is something in common on the days you feel the worse.  Good Luck, sounds like you are doing real well.  We are all rooting for you.


Veteran Member

Date Joined Apr 2004
Total Posts : 6056
   Posted 6/12/2006 4:29 PM (GMT -7)   
You guys are making me sort of glad that I can't afford lizard spit... :-)
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross

New Member

Date Joined Aug 2012
Total Posts : 1
   Posted 8/12/2012 9:30 PM (GMT -7)   
I had been using Byetta for 3 years. My doctor took me off of it last year because I was in the paramedic program & he was afraid I'd bottom out while doing my clinicals. He started me back on it a month & half ago & the nausea is a problem at times. I am a vegan & I found that if I drink plenty of fluids with my shot that it cuts down on the nausea. But today I don't know what happened but I took my shot at noon & had the nausea for 8 or more hours. It just wouldn't go away. I went exercising & I still had the nausea so bad that I couldn't take my second shot. My doctor is wanting to bump my dose to the 10mcg next month but I am afraid the nausea will be so bad I can't stand it. I am in college & it's hard enough to find time to eat right. Has anyone tried any home remedies for the nausea that works? Any tips would greatly be appreciated. Thank you.

Lanie G
Forum Moderator

Date Joined Nov 2006
Total Posts : 6028
   Posted 8/13/2012 7:17 AM (GMT -7)   
Welcome to the Forum, Devorah65.  I don't take byetta so I cannot give you advice from personal experience although I do know that diabetes drugs that can cause nausea are best taken with food.  Here is an excerpt from a diabetes blog website about controlling nausea when taking byetta.  I hope this helps: 
"But if we keep on eating anyway – like we always did in the bad old days before Byetta – we are bound to feel the nausea. The first eating strategy is small meals and maybe more meals or snacks.

What to eat is the second eating strategy. “I have to remember to keep the fat and spices miniscule,” one Byetta user wrote.

“Definitely avoid spicy or fatty foods,” another Byetta user wrote. For example, “I can eat a hamburger, but not a hotdog.”

I have always used a lot of red pepper in its many forms. But listening to my body, I am just not as attracted to hot stuff any more.

The recommendation to avoid fat may be even more important. When HealthCentral sent me to the American Diabetes Association’s June convention in Washington, I made sure to stop by the Byetta booth. While I was there, I got the chance to talk with a doctor who works for Amylin.

This doctor, unlike the one I spoke to at the customer support center, was willing to give advice about how to deal with nausea, as long as I don’t use his name. The key, he said, was to minimize the amount of fat that we eat.

When to eat is the third eating strategy. The general advice for Byetta is to eat from 1 to 60 minutes after taking it.

People who have waited more than an hour have reported nausea. In fact, the sooner you eat something after taking Byetta the less the chance of nausea.

“If I eat just as soon as I take the injection, it is much better,” another Byetta user wrote. “I found that if I inject about 20 minutes before eating, it is the perfect timing for me.
I must eat WITHIN one hour of taking the injection.
A word of advice – don’t take the Byetta and then forget to eat. I did that this AM. Family crisis. Took the shot and never ate breakfast. I had a miserable day feeling tired and weak. Whatever you do, make sure you eat something, even if it’s only a bowl of cereal.”

Different foods also affect people differently. I haven’t been able to see which foods are the worst culprits. So whenever you have a bad experience with a particular food, it’s best to go easy on it the next time.

Some foods help a lot of people in dealing with nausea. By far the food recommended the most often is ginger in its many forms – including ginger snaps, ginger gum, ginger ale, ginger pills."


So, the bottom line, as I see it, is to eat something when you're taking the byetta and to avoid fatty foods.  Also, since this may be an individual problem, make a note of what you eat and how you feel afterwards in order to understand which food makes you more nauseated.

Good luck.


diabetes moderator
diabetes type 2 controlled so far by diet and exercise
very low carb way of eating

Regular Member

Date Joined Jun 2012
Total Posts : 60
   Posted 8/13/2012 11:18 PM (GMT -7)   
My mom was on this for a while and she had to eat within 15 to 20 min after taking the shot. If she didn't she was severely sick!!! Also beware that she kept getting Pancreaitis because of the shots. She would quit the shots for a while then go back on them and it would do it again!! She finally had to just quit taking them.
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