diabetes and ace inhibitors

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New Member

Date Joined Oct 2006
Total Posts : 11
   Posted 1/30/2007 5:04 PM (GMT -7)   
 Hello everyone,
I haven't posted in a while but all your posts are very helpful to me. I was diagnosed as Type 2 last October. Have been on Metformin 1000mg/day and this is working well for me.
Recent labs showed A1c at 6, cholesterol 326, and triglycerides at 296, also elevated C-peptide ( I'm not sure what this is).
My doctor prescribed Vytorin 40/10 and Niaspan (which I won't take due to the flushing effect) and prescribed Lisionpril 2.5mg/day even though high blood pressure is the only thing I do not have.
Seems as though I am extremely tired since starting to take the ace inhibitor. And am wondering if this drug is necessary. The doctor said it is used to help the kidneys?????
Does anyone take an ace inhibitor that does not have high blood pressure? Fatigue seems to be one of the side effects, and this is such a low dose..... I was wondering if the fatigue will go away. 
Desperately need straight talk help.
Sick and tired of feeling sick and tired.

Lanie G
Forum Moderator

Date Joined Nov 2006
Total Posts : 6079
   Posted 1/30/2007 5:16 PM (GMT -7)   
Hello Patricia, I have "pre-diabetes" and am able to control my numbers by diet and exercise so far.   I take Accupril which is an ACE inhibitor because I do have high BP, but my doctor told me she would have prescribed it anyway to protect the kidneys.  I don't experience any fatigue with this medication.  I've been taking it for about 10 years now.  Maybe it takes time to get used to it or combined with other meds, it might make you tired, but that's something to ask your doctor or even the druggist.  Good luck!

Regular Member

Date Joined Dec 2006
Total Posts : 406
   Posted 1/30/2007 5:33 PM (GMT -7)   
Hi Patricia,

I take Niaspan (1500 mg per day) and found a way to beat the flushing!!! I take an aspirin 1/2 an hour before taking the Niaspan and after I do so, I go to bed! If I flush, I'm not aware because I'm sleeping! I get my labs back tomorrow so we'll see if it's helping my cholesterol.

Lanieg, why would your doctor have prescribed Accupril for you if you're able to control your diabetes with diet and exercise? Why would there be a need to "protect" the kidneys?

I've got sooooooo much to learn! Good thing my "Diabetes for Dummies" came today. Maybe I should busy myself with reading it!
Cheers -


age 52/Type 2 diabetic/"controlled" by diet and exercise

Lanie G
Forum Moderator

Date Joined Nov 2006
Total Posts : 6079
   Posted 1/30/2007 6:51 PM (GMT -7)   

Hi Ruth!  I've been on the blood pressure medicine, Accupril, for about 10 years for high blood pressure only, before dealing with pre-diabetes.   It's only since October that I've been monitoring my blood sugar because of high b.s. readings.  My doctor told me that sometimes ACE inhibitors are prescribed to diabetics to protect the kidneys because they're organs that can be damaged by the disease.   Well, I'm already taking the Accupril which is an ACE inhibitor so it's doing double duty.  (Sounds like a tongue twister.) 

Jeannie123 - I'm sure you can explain how diabetes affects the kidneys.  Help.  confused


Veteran Member

Date Joined Apr 2004
Total Posts : 6056
   Posted 1/31/2007 6:42 AM (GMT -7)   
I actually was on an ace inhibitor and had to stop it because the side effect of coughing was messing with my asthma. I am working on starting a new med at my next appointment. Here are some links for the ones who want to read up about diabetic kidney disease:

Diabetic Kidney Disease

Microalbuminuria In Diabetic Kidney Disease

The basic understanding of why renal disease develops in still not clear. It is thought that the excessive wear and tear by large sugar molecules on the tiny arterioles that supply the filtration system of the kidney eventually break down the system. Blood vessel damage is part of diabetes and this is the major reason for vision loss, circulatory problems that lead to amputation and heart attacks and kidney damage. The kidneys start to spill protein into the urine and often the backup of the filtration system can lead to edema and high blood pressure. Smoking is a high contributor to this problem because nicotine acts as a vasoconstrictor and adds to the pressure on the already overworked kidneys.

A word of caution: While researching about diabetes you will often come across websites that want to tell you that there is a big conspiracy by the drug companies and doctors to keep you 'sick'. They will state that they know about a 'miracle' natural remedy that is better for you than medication and will 'cure' over 60% or 70% or 120% or some outrageous number of diabetics if you will just start on their 'program'. These hucksters have no conscience. They don't care if you do unrepairable damage to your blood vessels while wasting time and health on their 'miracle cure' that only lowers blood sugars by a fraction. They cover their @$$es by offering a money back guarantee... Whoopee! How about giving back someone's sight after they wasted a couple of years on this stuff? The FDA in the US is trying to pin these guys down and already have them on the run. In Canada some of the basic ingredients of their 'cure' have been classified as drugs (which means they really do work but should be regulated by a doctor, not a website!) and now fall under medical dispensation laws. Please don't fall for their snake oil tactics. Discuss any and all 'natural' supplements, cinnamon capsules, etc. with your doctor so he/she can note this on your history. Work with your doctor on this and don't get lead astray.(Jeannie steps down from her soapbox and walks away.)
~ Jeannie
Forum Moderator/Diabetes & Fibromyalgia
~Please remember that 50% of all doctors graduated in the bottom half of their class!
Yours may be one of them...

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."
- Elizabeth Kubler-Ross

Regular Member

Date Joined Dec 2006
Total Posts : 406
   Posted 1/31/2007 2:34 PM (GMT -7)   
LOL ... you crack me up, Jeannie! I don't think I'm fodder for the snake oil salesfolk quite yet! tongue I think I am moving along, albeit slowly, toward that "acceptance" stage of the game. I am pleased to report that I no longer look at cake and feel sorry for myself. I recognize it for what it is now ... a treat for some and poison for me.

I've read just enough of "Diabetes for Dummies" to be dangerous now. skull I want to know the "whys" and "what fors" of just about everything! What I come up with over and over and OVER again is that tight blood sugar control and exercise are the KEYS to it all.

I called my doctor to get my lab results again, but they weren't read yet ... so I'm holding on for another day until I get my lab results back. If my cholesterol isn't down I'll ask about a statin. I don't want to fool around too much longer without seeing some real RESULTS.

Later -
Cheers -


age 52/Type 2 diabetic/"controlled" by diet and exercise

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