I don't drive, even though my seizures are well controlled - mostly because I am absent-minded (legacy of my family) ;)
I used to live alone for some ten years without any troubles. Sometimes my friends would give me a lift, that's all. Now my hubby is taking me everywhere, when he has time, of course. :) It's OK with me to be without driving license since I live in not all that big town with good public transport and not too expensive cabs.
I used to work in ad-agency as an art director, I still work sometimes in theatre (as free-lancer), but mostly live from translating. I work at home, yes, not because of E, but because of the nature of my work. I enjoy it a lot. My insomnia (side effect of Neurontin) isn't such a problem, since I can work whenever I want.