I would get a genetic profile done through 23andme.com and get the raw data interpreted through geneticgenie.org. I'd find my mutations along the methylation pathway and eat and supplement to bypass those genetic deficiencies. I'd then focus on maintaining the appropriate ratios on elements like Na/K, Zn/Cu, and Mn/Mb. I'd take supplements like Pectasol-C, D-Limonene, or Zeolite to decrease sequestered metals. I'd do a comprehensive stool analysis to make sure there wasn't a GI pathogen present that is causing the problems.