I have been treated for tension headaches and migraines since 2009. I was diagnosed with JME when I was 13. I'm currently on 150 topamax and 500 lamictal for seizures. I have tried antimigraines, analgesics, muscle relaxants, nonsteroidal-anti-inflammatory and steroids, ssnri antidepressants and obviously acetaminophen and aspirin for headaches . I have one every single day but the severity of it varies. Within the past few days I have noticed slight shaking and weakness in my hands. I have had Botox, never block injections and sphenocath. My MRI CT scan and blood work are all clean. I often have to go to the ER for pain. They give me Benadryl cocktail among other IV meds. They end with Diludid which helps but when is wears off the headache immediately comes back. I've tried massage therapy, chiropractic, acupuncture, diet change and exercise. Nothing has ever fully relieved my headache. I just got out of the hospital after 3 weeks. My neurologist is out of ideas. He referred me to Mayo and even they said there was nothing they could do. My neurologist is doing another round of Botox and referring me to a headache center. I didn't know if the Epilepsy could possibly contribute? I would really appreciate any help or advice anyone has to offer.