There is a very slight risk of seritonin syndrome with use of Imitrex and Cymbalta. However, I use both and my MD told me that I was not allowed to take more than one shot a a time. If I need more than 1 shot or if I need to take a shot after I have taken ultram that day, I have to go to the ER. I have been using this combo for several months with no issues.
BTW I believe that wellbutrin has the same problems.
A man cannot be comfortable without his own approval.-Mark Twain
FM & MCTD