Lyrica & Cymbalta

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New Member

Date Joined Jun 2009
Total Posts : 1
   Posted 6/28/2009 11:20 AM (GMT -7)   
I have been taking Lyrica for over a year now for Fibromyalgia, this past week my Dr. also had me to start taking Cymbalta. I question taking the two together, he said they work together. I have had 3 of the Cymbalta, I have been sick to my stomach and felt out of it. hot flashes. Is anyone taking the two and how long will the side effects last for the Cymbalta? Sissy

Regular Member

Date Joined Jun 2009
Total Posts : 286
   Posted 6/28/2009 1:43 PM (GMT -7)   
I am currently taking both together. I take 60mg of Cymbalta in the am and 150mg of Lyrica twice a day. I have no problems with interactions between the two medications at all. I do get some problems with heat sensitivity, but I'm not sure if thats because of the Cymbalta or just fibro sensitivity. Good luck!

"You were only given this life because you are strong enough to live it."

Dx: Fibromyalgia, Chronic Fatigue, Trigeminal Neuralgia, Migraines, Anxiety, Insomnia, Acid Reflux, RLS, Asthma.

Rx: Indomethacin, Buspar, Cymbalta, Lyrica, Requip, Nexium, Advair, Compazine, Lunesta.

Veteran Member

Date Joined Jan 2005
Total Posts : 9090
   Posted 6/28/2009 10:10 PM (GMT -7)   
Hi Sissy and welcome to our Fibromyalgia Family!!

I sure can see why you are questioning taking both of these medications. Many doctors prescribe them together and some try just one or the other. Depends on what your doctor thinks of the medications for you and how you tolerate them and hopefully if they are giving you any relief. Here's a quote from an online source about Lyrica.... It's basically an anticonvulsive and also works on the nerves to relieve pain.
Lyrica is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Lyrica also affects chemicals in the brain that send pain signals across the nervous system.

Lyrica is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy) or herpes zoster (post-herpetic neuralgia)."

Now on to's an antidepressant. So these two medicines are not the same but work on different areas to help relieve pain.

"Cymbalta is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Cymbalta affects chemicals in the brain that may become unbalanced and cause depression.

Cymbalta is used to treat major depressive disorder and general anxiety disorder. It is also used to treat a chronic pain disorder called fibromyalgia, and to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy).

You may have already know this but I printed it in case others were interested too. They are often used together but if the side effects are more than you can tolerate then call your doc right away. One thing they may try is cutting the dosage in 1/2 or 1/4 and see if that helps until your body is used to it. Both of these meds have some hefty side effects but there are people that have no side effects taking them. It's just how our bodies work.

Always remember it is YOUR body and YOU are in charge of what goes into it. You are hiring a doctor for his advice and in some cases he's the only one who can obtain medications you need. If you are uncomfortable taking the new one then speak up. Tell him you'd prefer to just stay on the Lyrica for now. It is your choice. One thing I've seen over the past year or so is doctors are pushing both of these drugs pretty hard. Partly because they are giving some good results in many people and partly because the drug companies are pushing them pretty hard.

One case in point is the familiar antidepressant Prozac, which is a fine medication used appropriately. I've tried it and had success for the limited time I was on it. While reading a research book recently I came across a quote from Peter Breggins book "Talking Back to Prozac" about this medication. It seems Eli Lily, the makes or Prozac have "promised to pay legal expenses to any doctor who is sued for malpractice when proscribing Prozac!" Shocking to me! Rare? My gut says maybe not.

We all have heard and read this stuff...some true, others not. But even with this type of thing out there I believe most doctors are good, honest people doing the best they can to help. My guess your doctor is like this too. Speak up with your doc and ask questions until you are satisfied...then decide if you will or will not take something he offers.

Good luck and keep us posted,
Co-Moderator Fibromyalgia & Chronic Pain Forums ~~~
Fibromyalgia, Ulcerative Colitis, Insulin dependent diabetic, PTSD, dermatitis herpetiformus, osteoarthritis, collapsed disk, and a few other side dishes.


If you ask what is the single most important key to longevity, I would have to say it is avoiding worry, stress and tension. And if you didn't ask me, I'd still have to say it.
George Burns

Regular Member

Date Joined Feb 2008
Total Posts : 278
   Posted 6/29/2009 5:52 AM (GMT -7)   
I was on Lyrica and Cymbalta. I quit Lyrica because it was causing me to be drowsy and in a fog all day long.
I recently tried to quit Cymbalta.....It has BAD withdrawal symptoms. I had to go back on it to stop the withdrawal and will try again when I have fewer responsibilites. Research the withdrawal for Cymbalta and you may decide to get out while the getting is good.....
Our attitude towards life determines life's attitude towards us. {Earl Nightingale} 
Fibro since 2005

Regular Member

Date Joined Mar 2005
Total Posts : 353
   Posted 6/29/2009 8:57 AM (GMT -7)   
I take both drugs with good results BUT I did have some crazy side effects when starting Lyrica and some very bad side effects starting out on Cymbalta but now everything is good, I do feel that the Cymbalta is helping with the pain issues and the depression now that my body has adjusted to it.
~ Carina~

Fibromyalgia, Bulging Discs (L4, L5-S1), DDD, Spinal Stenosis, Facet Joint Disease (Overgrowth), Osteoarthritis, Acid Reflux, Hypothyroidism, ADD, TMJ, Migraines, Depression and Anxiety.

MS Contin (time-release morphine), Lorcet, Abilify, Cymbalta, Lyrica, Zanaflex, Klonopin, Armour (thyroid), diaretic, Nexium, Triliplix (cholesterol)

“Any society that would give up a little liberty to gain a little security will deserve neither and lose both.” –Benjamin Franklin

Regular Member

Date Joined Nov 2008
Total Posts : 98
   Posted 6/29/2009 12:47 PM (GMT -7)   
I take Cymbalta and the only side effect I'm having is sweating a lot more than I did before.

Regular Member

Date Joined Sep 2012
Total Posts : 21
   Posted 9/4/2012 7:00 PM (GMT -7)   
I have taken cymbalta for years. I started taking it for GAD before being dx with fibro. I have just been rx Lyrica. I take my cymbalta at nite to sleep thru the side effects of nausea and dizziness I had. It passed in a few months. Now worried about side effects of Lyrica twice a day.
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