Neurontin VS Lyrica- anyone have an opinion?

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Regular Member

Date Joined May 2009
Total Posts : 99
   Posted 8/27/2009 2:39 AM (GMT -7)   
Hey all!
   I am on Neurontin (300 mg 2/day) and it worked for the first two weeks pretty well, but now (almost two months later) I can't really tell any difference (other than the side effects LOL).  I was just wondering if there was anyone out there who had tried both that had an opinion on one over the other?  I am sure that my next trip to the rheumy she will suggest that I up the dosage since as I understand it I am on a low dose and it did work in the beginning.  But since it has a nasty rep for weight gain (and I just switched from Zoloft to Cymbalta because the former has less of a chance of that- I gained 80 lbs over three years with the Zoloft NO MATTER WHAT I DID I couldn't take off).  I am hoping that maybe I can get back to a healthy weight by just eating well and getting whatever exercise I can without screwing with my fibro.  If anyone has an opinion one way or the other I would really be interested to hear about side effects, pain management, length you had or have taken either medicine or any other factor that you felt contributed to either drug's failure or success.  Thanks in advance gang- I am really frustrated and could use the help.
Dx'd with Fibromyalgia, High Blood Pressure, TMJ & Migraines
Meds & Supplements are Vicodin (as needed), Neurontin (300mgs 2/day), Cymbalta (60/day), Atenelol (50 mg/day) Biotin (5,000mcgs/day) & Yasmin (continuously).  Oh and a LOVELY retainer for the TMJ! 

Regular Member

Date Joined Jan 2008
Total Posts : 159
   Posted 8/27/2009 8:27 AM (GMT -7)   
Hi, I have taken Neurontin(gabapentin) Off and on for years. I took it about ten years ago for muscle spasms in my back and left hip. i was a wonder drug. I now take Lyrica for the fibro, I think it has help me with the nausea and some pain although not alot. I too will be seeing the rheumy in about 4 wks. She then said she wanted to put me back on the neurontin and then up the dose later. I was briefly on it before the Lyrica and I tell you, I didn't realize the difference on it, until i was off of it. Then the pain was unbelievable. shocked
So if i had to say, I like the neurontin, and the Lyrica does help a bit with the muscle pain.

I hope I helped a bit. good luck. Laura :-)
Cervical spine surgery 2004, C-section 1986, Cholecystectomy 1999, Thoracic and Lumbar injury 2000. Anxiety/depression 2008. Fibromyalgia 2009, Thyroidectomy 2008. Degenerative disc disease. IBS. Asthma, Rheumitoid Arthritis, Sacroillitis, Scolylosis, disc bulge in L5/S1.possible ankylosing spondylitis. Meds: Lisinophil, xoponex, symbocort, pulmocort, troponal, vitamin 2000 D, Vitamin B complex, Hydrocodone, Tylonal Arthritis, Cymbalta.prednisone and Lyrica

Regular Member

Date Joined May 2009
Total Posts : 138
   Posted 8/29/2009 9:48 AM (GMT -7)   
i was very interested in reading about the use of neurontin for fibro. i tried it several years ago for restless legs syndrome. it did not work. i do not remember what my pain was like then so i dont know if neurontin had any effect. maybe i wasnt even on it long enough. i have a dr. appt. in about 3 weeks. even though my pain level has improved recently, you can bet ill ask about using neurontin for fibro. thanks for posting!

Veteran Member

Date Joined Apr 2004
Total Posts : 6056
   Posted 8/29/2009 12:37 PM (GMT -7)   
A few years back one of our members posted that her doctor was starting her on a new drug called Lyrica and she was interested in all of our opinions. None of us had heard of it and so I did my research. The only thing I could find on the net was an investor's column and it explained that the company who owned Neurontin needed a new med to promote because Neurontin was going generic. They had developed a new med that was a slightly different formula than the Neurontin and thus would have a few years of royalties to help them along. The new med was Lyrica and it was for severe nerve pain (I think for shingles that all the baby boomers are showing up with...?) Anyway, shortly after that it was approved for fibro and the advertising campaign was on! If you have drug insurance it's worth a try... but if you're like me and buying your own I'd stick with the older generic gabapentin. Just my 2ยข.
~ Jeannie, Forum Moderator/Diabetes & Fibromyalgia
I know God will not give me anything I can't handle. I just wish that He didn't trust me so much. ~Mother Teresa

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."- Elizabeth Kubler-Ross

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