Anyone have success with Sam-E?

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New Member

Date Joined Dec 2009
Total Posts : 4
   Posted 12/22/2009 5:40 AM (GMT -7)   
I'm pretty new to fibro and still trying to decide if I want/need to go on prescription medication to manage my pain. I'd really like to avoid that if I can, and I have determined that the majority of my pain is stress-related...and I'm getting stressed over the tiniest things right now. A friend of mine has SAD and she is taking Sam-E and she said it is helping her tremendously. She said little things that would normally stress her out aren't anymore. I'm also having MAJOR sleeping issues and supposedly Sam-E is supposed to help with that too. So I'm thinking I might try it before I take the plunge into prescription meds. I'd like to hear if anyone has had success with it. And if so, what brand do you take? I don't really know anything about it but I've heard each brand is a little different, and the mg's are different.  Thanks! :)

Forum Moderator

Date Joined Apr 2005
Total Posts : 17497
   Posted 12/22/2009 6:13 AM (GMT -7)   
Hi, Zep, and welcome!  I have never heard of SAM-E but maybe someone on the forum has.  We do have people that suffer from SAD that use light boxes and really like them.  This would be another option for you.
I don't take prescription medication for my fibro.  I use ibuprofen with food, extra strength Tylenol, malic acid/magnesium supplements and vitamin D supplements for my pain and fatigue.
Try to relax.  This time of year is so hectic and I think we just get more stressed over things.  Take one day at a time.  Try not to think too much in the future.   
Check out the Fibro 101 thread.  There are links with good information about fibromyalgia, including a list of symptoms and also info on malic acid/magnesium supplements and vitamin D.  Many fibromites are deficient in these.  My doctor has me taking 3,500 IU of vitamin D a day and I'm still not quite in the normal range! 
I so glad  you found us and joined in.  Don't hesitate to ask question because we are here to help you.  I hope to hear more from you soon.
Forum Moderator/ Fibromyalgia
Fibromyalgia, Crohn's Disease, Ostomy, Diabetes, Autoimmune Inner Ear Disease, Osteoporosis
God does not give us a spirit of fear, but of power and of love and of a sound mind.    2 Timothy 1:7

Nana Monster
Veteran Member

Date Joined Jul 2009
Total Posts : 957
   Posted 12/22/2009 7:04 PM (GMT -7)   
If I'm not mistaken wasn't it SAM-E that James Coburn was taking when he started acting again.
It was about the time he was making "Maverick" with James Garner. Before taking it he was
bedridden from the pain of arthritis. I remember seeing an ad in the Sunday Paper for it sponsered
by him. I haven't taken it personally but check into it.
Nana Monster

New Member

Date Joined Dec 2009
Total Posts : 4
   Posted 12/23/2009 5:40 AM (GMT -7)   
Thanks guys. I actually ended up going to the dr yesterday, they had a cancellation and asked me to come in (I was supposed to go tomorrow). I asked him about Sam-E and he said I could try it if I want, but he wouldn't recommend it because I guess some of the possible side effects are very similar to fibro symptoms (joint pain, etc). He gave me a sample of Lyrica to try, and I go back to him next week to see how I'm doing on it. I've heard terrible things about it so I was hesistant to try it but I'm glad he wants to see me in a week again...rather than just giving a prescription and telling me to come back in a month or something. He also said I should take a vitamin D supplement, just in case my levels are low.
I'm not thrilled about being on a prescription med, but I'm getting desperate for help so I'm willing to try it right now. I've missed over 80 hours of work in the past 2 months. THANKFULLY my employer has been extremely understanding...but I know I can't continue on like this forever. I'm hoping the Lyrica helps my pain, which then I really think will help my sleep because I'll be less stressed over the whole thing (if I dont have to continue missing work and being in constant pain). So I'm just keeping my fingers crossed that this works for me!
Thanks again!

Veteran Member

Date Joined May 2006
Total Posts : 1477
   Posted 12/23/2009 10:23 AM (GMT -7)   
Hi, what I have learned about SAME is to take it on very empty stomach away from food. like first thing in morning with lot of
water. When I take it that way I sleep better and also have better digestion which automaticlly cuts down on pain and depression.
When I tried it a year ago I was taking it with food and was actually feeling achier in my joints. Also I read somewhere that only buy
SAME in foil wrapper not loose in bottle and check date on box. I ove that lyrica commercial on TV. The woman looks so pain free but the side effects scare me. I don't understand what it really is chemical wise. antidepressant? antiinflamitory?
For me..state of mind is everything and with all medications I think there is a trade off with side effects. The thing about SAME that gives
me peace of mind is I haven't heard the side effects like with pharmacueticals. But for sure there was a big difference between an empty stomach and if I took it after eating. empty stomach it worked. food in stomach acctually made me feel worse.

Nana Monster
Veteran Member

Date Joined Jul 2009
Total Posts : 957
   Posted 12/23/2009 11:17 AM (GMT -7)   
In Arthritis Today a lot of the side effects of Cymbalta, Lyrica, etc are blood disorders, brain disorders,
kidney disorders or failure, liver disorders or failure, lupus symptons, heart problems or failure,
and one of my all time favorites.......CANCER. Scares me so bad I stopped taking all of them. They
wanted me on Lyrica but threw out the prescription. I've been on so many meds (30 years worth)
that it's a wonder it didn't do more damage than just losing my back teeth to the dry mouth.

Regular Member

Date Joined Jun 2009
Total Posts : 286
   Posted 12/23/2009 7:43 PM (GMT -7)   
I'm on Lyrica. It has helped me alot with my nerve pain...and especially my trigeminal neuralgia. Yes, the side effects are scary, but side effects of many medications are scary. I just take what I hear with a grain of salt.
"Anyone can give up, it’s the easiest thing in the world to do. But to hold it together when everyone else would understand if you fell apart, that’s true strength."

"You were only given this life because you are strong enough to live it."


Dx: Fibromyalgia, Chronic Fatigue, Trigeminal Neuralgia, Migraines, Anxiety, Insomnia, Acid Reflux, RLS, Asthma.

Rx: Celebrex, Buspar, Savella, Lyrica, Requip, Nexium, Symbicort, Compazine, Lunesta.

Supplements: Vitamin B12, Vitamin D, Vitamin C, Ginseng

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