I take 60mg in the morning and the same at night, in addition to all my other meds. I felt it starting to work by the second week - it lifted my mood a bit (and I didn't realize I was mildly depressed) and I didn't feel the overall aching sensation I normally have.
I have been experiencing side effects such as loss of appetite and hot flushes/heavy sweating, but I'm not sure if that's from the Cymbalta, or other meds, or a combo. Overall, any negatives are outweighed by the positives I'm getting.
Good luck with it...I hope it provides you with relief!
Conditions: Fibromyalgia, Chronic Pelvic Pain, FAI, Reynauds, IBS, Interstitial Cystitis, Surgical Adhesions, Ophthalmic Migraines, Severe Hot Flashes (Surgical Menopause and drug related), plus physically unable to vomit due to Nissen, and I have extremely tiny veins...a joy for blood work or IV's)
Surgeries: Appendix, Uterus, Nissen Fundoplication for GERD, Left Ovary, Gallbladder, Right Ovary, TVT
Medications: Oxycontin, Tramacet, Cymbalta, Flexeril, Clonidine plus Vitamin D and Multi-Vitamin daily