how does amiltriptyline work?

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Sera Smiles
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Date Joined Nov 2006
Total Posts : 671
   Posted 3/14/2010 2:59 PM (GMT -7)   
Please explain to me how taking amiltriptyline at night to combat pain in the day is possible?  I am finding it so hard to trust this. My pain is at an 8, an 8 is how I start each day. I am not what you would call a "complainer", I am just letting you know how bad its gotten over the past 12 months. So I am putting all my hopes on this new med, almost like a hail mary pass rolleyes I feel like a teenager in rebellion of this health challenge. At first I tried taking 10mg in the day, but for the past week I have been trying to do it right, taking 30mg at night. The good news I don't need trazadone for sleep [has anyone been on trazadone? I need more personal info on this med.] My pain has gotten so bad that is affecting my attitude and my faith. What can I reasonably expect from this med? I didn't realize how bad I was doing, physically and emotionally, until the doc offered this. I hope this makes sense. Any thoughts and personal experiences on how this med helps with pain will be most appreciated.
"A butterfly is most vulnerable immediately after its' metamorphosis."
Dx FM- 2003
Rx Meds- Ultram, Toprol, Cymbalta, Ambien
OTC meds [PRN]- Aleve, Benadryl, B Complex, Vitamin D, Omega 3, Multi Vitamin

getting by
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Date Joined Sep 2007
Total Posts : 42056
   Posted 3/14/2010 3:34 PM (GMT -7)   
It sounds like it has something to do with your quality of sleep. That is what I take on it. I have never taken it. I also heard that it helps other medications to work better, such as pain medications. I think that you take it at night because it is sedating. Have you asked your doctor about this? I think he would have the best answer, or maybe look it up on the internet. Hopefully somebody here will have more information than I do for you.

Hugs, Karen
  Moderator-Depression and fibromyalgia
fibromyalgia, Chronic fatigue, depression,allergies

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Date Joined May 2009
Total Posts : 51
   Posted 3/14/2010 6:31 PM (GMT -7)   
I was on this for awhile and at first it worked great for me! I loved it! But once we had to start uping the dose I didn't enjoy it as much and I started at a very very small dose 5mg. It is my understanding that they prescripe this med (as well as trazadone) to improve the quality of sleep. With fibro you are not getting restful sleep with is causing your body to not heal itself which only adds on to the pain. And I believe that both of these meds have proven to help with pain througout the day as well. This is what I understand of these meds.
Pain is temporary.  It might last a minute, or an hour, or a day, or a year but eventually it subsides and something else will take its place.  If I quit, however, it lasts forever.
Fibromyalgia & Endometriosis
Trazasdone, Yaz, tylenol, aleve

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Date Joined Apr 2004
Total Posts : 6056
   Posted 3/14/2010 7:14 PM (GMT -7)   
This med, along with your Cymbalta, should be helping with your serotonin levels. We need serotonin to regulate our mood, help with our pain threshold, regulate circadian rhythms and to help with appetite, among other things. It has drowziness as a side effect so it is often prescribed at night to help with sleep. This medication may take several weeks to build up an effective feeling in your body. It doesn't work like a pain reliever, with relief in a half hour. Hope it starts helping soon.
~ Jeannie
Moderator for Fibromyalgia and Diabetes

Nana Monster
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Date Joined Jul 2009
Total Posts : 957
   Posted 3/15/2010 1:14 PM (GMT -7)   
I took amitriptolyne for about 6 months. It helped me to sleep a bit better,but not so much with the pain. The dry mouth was
horrible and when my hair started falling out at an alarming rate I stopped taking it altogether. If you take True Calm by NOW
brand herbals, it works in the same way without hurting you. I sleep great and most of the spasms have stopped.

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Date Joined Nov 2008
Total Posts : 5953
   Posted 3/18/2010 4:11 PM (GMT -7)   
I've been on Nortriptyline for 18 years - it's just 1 molecule different from Amitriptyline (it's less sedating.) I take 25 mg at night, but for the first few years, I took 50. My sleep was so chronically interrupted by waking. My pain is definitely better than it was back then...well, lately the intensity has been creeping up again, so I'm trying additional drugs, too...but my doctor always wants to keep me on the Nortriptyline. Actually, he himself takes Amitriptyline for sleep, though he says it doesn't always work! Good luck!!
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