Doc started me off with Lyrica 2 years ago. I found it best to start my doseages at bedtime so as not to have to deal with side effects of feeling light headed, dizzy, during the day. It helped to do so and now any new meds I start at bedtime. Lyrica also gave me dry-mouth when I first started it for a bit which eventually went away. I have gained about 30 lbs over the last 2 years while on it, but thankfully for the last 6 months my weight has held steady. I haven't been happy about the weight gain (especially since it's ALL in my abdomen, so I look pregnant) but it, like all of our meds is a trade off pain between side effects. I'm on 150mg 2 x day. For awhile I was on 150mg 3 x day, but the side effects at that doseage were way way too much for me so I dropped the midday dose. We tried it at a lower doseage for the midday dose, but the side effects were still too much. Lyrica has made a difference in my pain and within a few days of starting found I had more energy and didn't hurt as much. It was not enough to take away my pain, or even knock it down completely and within 6 months we added other meds to help.
I hope this answers your questions a bit.
Dx'd with fibro, oa, and carpal tunnel.
Rx's: Lyrica 150mg 2x day, Savella 100mg 2x day, Nortriptylene 100mg at bedtime, vitD3, fish oil