Like any medicine they all affect us very differently. I've taken percocet for several years and it does do a good job with my pain, especially when it's gone wild! Yes, pain does come and go but each of us has a different level of "come" and of 'go'. For me the 'go' is feeling hurting most all over from the pain. And the 'comes' is hard to describe. I makes me hide is the best way I can describe since I don't want anyone to see me in that kind of pain.
Personally I don't get any loopy or 'speedy' feeling from it. The worst I have is feeling sleepy. For me it hasn't been too much of a problem. After I'd been on it for a couple of years I began to not feel as awake as I should when I needed to drive. I asked my doctor about
it and he prescribed Provigil. That really made a huge difference.
There are people who can't tolerate any kind of pain medications, even aspirin, and others who need a huge dose just to get any relief. There's no way for you or your doctor to know how you will react until you try it. Be very aware of how you are feeling. Keep a journal and write down not only how much you've taken but how you feel. Here's a link to a copy of a great pain journal. Copy a page for each day and fill them out regularly. It's helpful for you to take your journal to your doctor appointments so he/she too can see how you are reacting to medications and what your pain is like.
Hope this helps...
Moderator on the Fibromyalgia and Chronic Pain forums
Daily Donnybrook: Fibromyalgia, Insulin Dependent Diabetes. Ulcerative Colitis, Rare form of Dermatitis, Collapsed Disk, Osteoarthritis (especially in right hand and neck) and a couple of other adjunct agitations.
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