Posted 4/14/2013 10:34 AM (GMT -6)
I have been suffering from fibro pain for 3 years since I was diagnosed with Lupus. I just joined this forum because I came across some new breaking NIH research that has changed my life (see abstract below). They did a study giving FM sufferers 300 mg/day of Coenzyme Q10, because apparently most people with FM are low on CoQ10. I gave it a try and after 4 days I was able to titrate off my pain meds. It was like the pain just melted away. It felt (and still feels) like a miracle. I want to share this with as many people as I can with the hope that it can help even 1 person. I know how it feels to suffer day in and day out. It is devastating, and no way to live. Give this a try and see if it helps. It certainly won't hurt to try.
I take Life Extension's 100mg tabs of CoQ10, but there are tons of other distributors. Try to pick the best quality you can.
Antioxid Redox Signal. 2013 Apr 6. [Epub ahead of print]
Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?
Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, Fernández-Rodríguez A, Sánchez-Alcazar JA.
1 Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla , Sevilla, Spain .
Abstract Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology. We have investigated the effect of CoQ10 supplementation. We carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300 mg/day) on 20 FM patients. This study was registered with controlled-trials.com (ISRCTN 21164124). An important clinical improvement was evident after CoQ10 versus placebo treatment showing a reduction of FIQ (p<0.001), and a most prominent reduction in pain (p<0.001), fatigue, and morning tiredness (p<0.01) subscales from FIQ. Furthermore, we observed an important reduction in the pain visual scale (p<0.01) and a reduction in tender points (p<0.01), including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis, and AMPK gene expression levels, associated with phosphorylation of the AMPK activity. These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM. Antioxid. Redox Signal. 00, 000-000.