I used Cymbalta with very good results for about 2 and a half years. After that, it did not seem to help me anymore. It was very hard to come off, and I felt sick and yucky for months, even though I tapered off it very slowly, as suggested. I also had good results with Savella, and that lasted about the same amount of time, but was not hard to get off.
Now I am managing it by eating gluten free, taking tramadol for pain at night, and a muscle relaxer as needed. I also get medical massage each month.