Thank you, fellow nerd, for this new study, which I had not seen! It's interesting that there are these several fibro/CoQ-10 studies. Cordero led studies , Garrido-Maraver (with Cordero) Castro-Marrero (with Cordero), Miyamae's (Juvenile fibro). It would indicate a mitochondria problem. Perhaps too many ROS/reactive oxygen species (a Cordero study)? Maybe RNS as well?
One warning, on my thread about amitriptyline being mitotoxic (at myPatientMatch), I shared that I read that too much CoQ-10 can also be mitotoxic. Dr Sinatra suggests divided doses, which sounds smart, and also keeps levels higher.
There is also a ME/CFS study I saw, led by Castro-Marrero (with Cordero). /www.ncbi.nlm.nih.gov/pmc/articles/PMC4346380/
As with this above study, I also find adding NADH helps me with fatigue, but so far, of two brands of NADH trialed, only Pro-Health's brand helped me. And I'm not going to trial more brands without a good recommendation first. NADH is also used in the Electron Transport Chain.
New patients if you have missed the videos
Electron transport chain/oxidative phosphorylation. You don't need to fully comprehend all of this, it's just helpful to be slightly familiar when considering supplements or when reading research and forums.
--- Handy phrases to know: "oxidative phosphorylation" (adding one phosphate to the two that are already in ADP), electron transport chain/ETC, "cellular respiration" (notice exchanges of oxygen, hydrogen, water), the "cytochrome" and some things used in the ETC
ATP (low in fibro and ME/CFS)
Video. Dr Sinatra explains why CoQ10 /youtu.be/7R2xIIzcrNs
If you are trying to go soy-free, Healthy Origins has soy-free Ubiquinol. It has been cheaper on iherb than Amazon. Just need to order enuf to get free shipping. But that is the Ubiquinol form. Some ME/CFS patients have found they do better with Ubiquinone form. (That's "regular" CoQ-10). Dr Sinatra studied 12 of his patients using one form, then, using nothing, then switching to the other. He says that considering the cost and results of his study, he is recommending the Ubiquinone (regular CoQ-10)
( Healthy Origins is expensive)
Cardiologist Steve Sinatra's small study compares Ubiquinol use to Ubiquinone use.
Only 12 people.
Thanks for all the info and links! Yes, the fibro/CoQ10 connection seems to be a research interest for that particular scientist. Hopefully others will take the hint. Would love to see a large clinical trial, but funding is always an issue.
Sinatra was an author on this study which found that solubilized (water and fat-soluble) forms of CoQ10 are better absorbed than powders and softgels: https://www.ncbi.nlm.nih.gov/pubmed/9565826. This review looked at a variety studies and concluded that both solubilized ubiquinol and CoQ10 are better absorbed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Plasma+coenzyme+Q10+response+to+oral+ingestion+of+coenzyme+Q10+formulation.