Hi Ebonyeyez. Hopefully this doesn't need edits before my tablet runs out of juice!
My SED(ESR) remained elevated for years, but I don't know what it is lately, cuz I am avoiding Dr appointments.
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Post Edit, December 2017
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma. March 2017./www.ncbi.nlm.nih.gov/m/pubmed/28424559/
Also a Post Edit:
11/8/2015 Presentation @ meeting of American College Rheumatology & AHRP
Higher Levels of Pro-Inflammatory and Lower Levels of Anti-Inflammatory Cytokines Are Present in Fibromyalgia Patients/www.healingwell.com/community/default.aspx?f=24&m=3548138
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Original thread reply resumes here.
The first link I have for you is to a thread at HealingWell about
some of the Fibromyalgia inflammation studies. CRP (c reactive protein, or can be hs-crp)and SED (also called ESR/erythrocyte SEDimentation rate) should be in bold letters there, hopefully, can't remember for sure. These are some studies that looked for specific inflammatory cytokines, CRP, SED, or other markers of inflammation. These are small studies, we can't call the evidence conclusive, but blame that on a lack of research money for fibro from the oh-so-lame NIH. I haven't sought out such studies for such a long time, so there may be others in recent years, idk.www.healingwell.com/community/default.aspx?f=24&m=2756942
A couple of the CRP findings I see, searching just now in my "Notes" app:
"There were no statistically significant changes in biomarker levels, although total group ****C-reactive protein [CRP]***** was elevated at baseline (4.7 mg/L), indicating an inflammatory process. "
Title: Effects of guided imagery on biobehavioral factors in women with fibromyalgia. [number: 72 women]
Journal of Behavioral Medicine 2014. Menzies.
Inflammatory/Stress feedback dysregulation in women with fibromyalgia.
Bote ME, García JJ, Hinchado MD, Ortega E.
Group of Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain.
Paraphrasing: 100% of the fibromyalgia group had markers of an inflammatory state and altered stress response. They say that was demonstrated by high circulating levels of interleukin 8, a major mediator of inflammatory response (an inflammatory cytokine), and ***C-reactive protein***, which rises in response to inflammation.
There is a brand new post about
glial cells and Neuroinflammation. I can't even remember if I should explain glial cells to you....maybe they are explained in this. If it's as clear as mud, then what you want to do is watch Linda Watkins explain glial cells' influence on Neuroinflammation, at the next link, a YouTube video.
Just part of it:
"The increased pain sensitivity in FM could all come down to immune cells in the brain called glial cells (microglia, astrocytes, and oligodendrocytes). Despite the fact that glial cells are much more common than neurons, they were all but ignored until about
10 years ago. They’re being ignored no longer. When activated, these cells pour out inflammatory factors that tweak the pain pathways, clean up cellular debris and kill pathogens.
When they’re turned on full-time, glial cells can have pathological effects. They’re linked to pain sensitization because they emit many factors (brain derived neurotrophic factor (BDNF), IL-1B, TNF-a) known to send our pain-producing nervous system pathways into a tizzy. When they’re turned on full-time, they produce a state of chronic inflammation found in many central nervous system disorders."
Linda Watkins, PhD, speaking I believe to imaging professionals about
chronic pain and glia....2011? Pick a good brain day to watch./youtu.be/KYyvEyroDgk
And there is the topic of mast cells, (which btw engage in cross talk with glial cells), and may be key for many fibro patients. Certainly for me. I have seen mast cells described as the "gatekeepers of pain". They are able to activate and release mediators of inflammation.
To understand mast cell disorders see my thread at myPatientMatch (.com), use the search feature, search for the word "Reference". The first section explains how mast cells work, in pretty general terms. Don't try to read it all. But skip to the Fibro/mast cell research, which is at the fifth section/avatar at the Reference Thread to share mast cell info.
btw, A Mast cell patient reassuring another member, wrote on a thread about
CRP today: "My CRP has been as high as 81, as low as .5. It's one of the few blood tests that actually shows how I feel."
In this HW thread, I linked to some patients' posts about
using the steroid prednisone to help fibro inflammation/pain, here:www.healingwell.com/community/default.aspx?f=24&m=3686174
(Steroids NOT recommended, unless used very short term, or if there is no other choice. Some mast cell patients do need them at times.)
Post Edited (Rockon) : 12/29/2017 9:51:53 AM (GMT-7)