My first impression of what I was reading and watching about
LDN was that it was positively affecting an immune cell called Glia. Glia are central nervous system and peripheral nervous system...I'm not positive, but maybe microglia are the ones in the peripheral nervous system?
(There is a woman in a YouTube video who goes through and explains the various roles of the different types of Glia. I need to watch it again. I only listened to it while in the bath.)
The best video I have seen about
blocking toll like receptor 4 /TLR4 m!on Glia (which is what Younger says they think LDN does) is a lecture by Professor Linda Watkins to imaging professionals. I can get you the link if you like. It's a little long, but so good. On YouTube.
The theory is that Glia perpetuate chronic pain states by releasing mediators of inflammation. It's a low level inflammation,and does not necessarily turn up on everyone's regular type of blood work, meaning not everyone with inflammation would have a high CRP (c reactive protein) or SED rate. The rate at which the proteins in a tube of blood settle to the bottom. It's also called erythrocite sedimentation rate, or ESR...same as SED.
There are some small fibro/LDN studies by Jared Younger and his associates. I think Mackay (Mackey?) was also on the team's very first one, a tiny pilot study of only maybe nine patients. Then they did a follow up....also small. They realized when they looked at all of their data at the end, that the fibro patients with a higher SED rate at the start had a better response to LDN than others. I figured if they did another, they would measure SED and maybe other inflammation markers both before *and* after LDN therapy.. They didn't measure after treatment.
Then Younger took some team members from #2 medical center Stanford, and took Univ of Alabama up on an offer to start a new Neuroinflammation Lab, doing research only. I'm not positive that Parkitney is at UAB (Birmingham, Alabama USA), but in an email Younger wrote about
the third (small) fibro and LDN study. Maybe Cort Johnson has blogged about
it...seems to be a vague memory I have.
If you use LDN, and have Hashimoto's, some autoimmune condition will improve, and hashi's is one. You have to know the symptoms of being hyperthyroid...if you get weird symptoms that are not Hypo symptoms, it may be that your thyroid hormone dose is too high for the improved you. I just told someone in yet another type of group about
this. She had gotten hyperthyroid while on LDN, and needed a dose adjustment. No one had warned her.
At myPatientMatch there at least 80 reviews of LDN. perhaps mostly from ME/CFS patients.
I also see that some mast cell patients (over active mast cells) are finding it helps. I don't know if that's because Glia and mast cells are known to activate each other's immune response, or if LDN actually stabilizes mast cells, also.
I will also edit in another thread address.Pretty sure It will have links to the early Younger studies.
Edit. Here is a link. To find the Yonger studies real fast, I just added in a row above it that says
LDN ° LDN ° LDN ° LDN ° LDN ° LDN ° LDN ° LDN ° LDN ° LDN °LDN °LDN ° LDN
And prolly go to the LDN "treatment" reviews (or find them at myPatientMatch. -.com... on your own) I know that we had a few trouble shooting threads there at myPM about
tricks for getting around adjustment problems. But the site changed servers and old threads can be impossible to find some times.munlessmits me or my tablet? Possible. Maybe some of that into is saved in this HealingWell thread that I am gonna link to. At the link, skip down to the Younger/LDN studies. No need to read everything else. It's not that far down, btw.
I sure hope to see a review from you, at myPM, saying it went very well and was helpful. Oh yeah, the compounding pharmacy can be important. I see people saying they likeLDN from Skips Pharmacy. Cort Johnson blogged about
that a few yrs ago. An MS group has a section on using KDN, and I saw people here liked Skips....maybe others as well. It's been a long time since I looked.
Oh now I remember that Cort Johnson did blog about
that last Parkitney LDN study. He said Jared Younger said about
it that prolly we not yet figured out proper dosingz so maybe the third study was a little disappointing.
I hope I don't have too many autocorrect and Rockon mistakes,mcuz don't want edit this.tired, tired, tired! So what's new? My horrid neighbors up above my apartment, lol.
The Linda Watkins' lecture I mentioned is here:/youtu.be/KYyvEyroDgk
Post Edited (Rockon) : 11/8/2017 11:06:11 PM (GMT-7)